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Tbio
ARR3
Arrestin-C

Protein Summary
Description
May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins. The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307959
  • ENSP00000311538
  • ENSG00000120500
  • ENST00000374495
  • ENSP00000363619

Symbol
  • ARRX
  • CAR
  • ARRX
  • cArr
  • MYP26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
tissue sample
0.75
gene perturbation
0.61
interacting protein
0.6
hub protein
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.16   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.16   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Wnt signaling pathway
PathwayCommons: pid
CXCR4-mediated signaling events
PathwayCommons: pid
Visual signal transduction: Cones
PathwayCommons: pid
Thromboxane A2 receptor signaling
PathwayCommons: netpath
FSH
Name
Explore in Pharos
Explore in Source
Wnt signaling pathway
CXCR4-mediated signaling events
Visual signal transduction: Cones
Thromboxane A2 receptor signaling
FSH
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (115)
1 – 10 of 115
ARRB2
Tbio
Novelty: 0.00180049
p_int: 0.999999919
p_wrong: 8.1e-8
Score: 0.375
Data Source: BioPlex,STRINGDB
CXCR4
Tclin
Family: GPCR
Novelty: 0.00033459
Score: 0.931
Data Source: STRINGDB
GNA15
Tbio
Novelty: 0.0018171
Score: 0.924
Data Source: STRINGDB
TBXA2R
Tclin
Family: GPCR
Novelty: 0.00629658
Score: 0.922
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00156526
Score: 0.921
Data Source: STRINGDB
SLC9A3R1
Tbio
Family: Transporter
Novelty: 0.0026167
Score: 0.91
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.00176666
Score: 0.909
Data Source: STRINGDB
RAB11A
Tbio
Family: Enzyme
Novelty: 0.00196791
Score: 0.909
Data Source: STRINGDB
GNA14
Tbio
Novelty: 0.12434273
Score: 0.907
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00031121
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  124.16

PubMed score by year
PubTator Score  557.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer