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Tchem
CHRNA7
Neuronal acetylcholine receptor subunit alpha-7

Protein Classes
Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it un ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306901
  • ENSP00000303727
  • ENSG00000175344
  • ENST00000437966
  • ENSP00000399087
  • ENST00000454250
  • ENSP00000407546

Symbol
  • NACHRA7
  • NACHRA7
  • CHRNA7-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.73   (req: < 5)
Gene RIFs: 215   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.73   (req: >= 5)
Gene RIFs: 215   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 787
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 7 subunit
467639
Macaque
cholinergic receptor nicotinic alpha 7 subunit
574230
Mouse
MGI:99779
11441
Rat
RGD:2348
25302
Dog
cholinergic receptor nicotinic alpha 7 subunit
488696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 7 subunit
Macaque
cholinergic receptor nicotinic alpha 7 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic alpha 7 subunit
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P36544-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Postsynaptic nicotinic acetylcholine receptors
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Postsynaptic nicotinic acetylcholine receptors
Gene Ontology Terms (57)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ARUK-UCL
Protein-Protein Interactions (79)
1 – 10 of 79
CHRNB2
Tclin
Family:  IC
Novelty:  0.01251655
Score:  0.937
Data Source:  STRINGDB
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
Score:  0.933
Data Source:  STRINGDB
CHRNA4
Tclin
Family:  IC
Novelty:  0.00494934
Score:  0.926
Data Source:  STRINGDB
CHRNA6
Tchem
Family:  IC
Novelty:  0.03991261
Score:  0.924
Data Source:  STRINGDB
CHRNA2
Tchem
Family:  IC
Novelty:  0.02542208
Score:  0.924
Data Source:  STRINGDB
CHRNA5
Tbio
Family:  IC
Novelty:  0.00425291
Score:  0.923
Data Source:  STRINGDB
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
Score:  0.923
Data Source:  STRINGDB
CHRNA1
Tclin
Family:  IC
Novelty:  0.01393364
Score:  0.922
Data Source:  STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
Score:  0.922
Data Source:  STRINGDB
CHRNB3
Tchem
Family:  IC
Novelty:  0.031456
Score:  0.922
Data Source:  STRINGDB
Publication Statistics
PubMed Score  181.73

PubMed score by year
PubTator Score  278.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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