You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CHRNA7
Neuronal acetylcholine receptor subunit alpha-7

Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it un ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306901
  • ENSP00000303727
  • ENSG00000175344
  • ENST00000437966
  • ENSP00000399087
  • ENST00000454250
  • ENSP00000407546

Symbol
  • NACHRA7
  • NACHRA7
  • CHRNA7-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.45   (req: < 5)
Gene RIFs: 215   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.45   (req: >= 5)
Gene RIFs: 215   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 905
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11