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Tbio
ATP5F1C
ATP synthase subunit gamma, mitochondrial

Protein Summary
Description
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. This gene encodes a subunit of mitochondrial ATP synthase. Mi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335698
  • ENSP00000338568
  • ENSG00000165629
  • ENST00000356708
  • ENSP00000349142

Symbol
  • ATP5C
  • ATP5C1
  • ATP5CL1
  • ATP5C
  • ATP5C1
  • ATP5CL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.61   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.61   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
1
2
2
95.9
red blood cell density measurement
1
1
1
42.3
mean reticulocyte volume
1
1
1
38.8
late-onset Alzheimers disease
1
1
0
6.1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
2
95.9
red blood cell density measurement
1
42.3
mean reticulocyte volume
1
38.8
late-onset Alzheimers disease
0
6.1
38.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP synthase F1 subunit gamma
VGNC:49012
450294
Macaque
ATP synthase F1 subunit gamma
713768
Mouse
MGI:1261437
11949
Cow
ATP synthase F1 subunit gamma
VGNC:26301
327668
Opossum
ATP synthase F1 subunit gamma
100011414
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP synthase F1 subunit gamma
Macaque
ATP synthase F1 subunit gamma
Mouse
Cow
ATP synthase F1 subunit gamma
Opossum
ATP synthase F1 subunit gamma
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P36542-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Formation of ATP by chemiosmotic coupling
Reactome
Metabolism
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Formation of ATP by chemiosmotic coupling
Metabolism
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Protein-Protein Interactions (331)
1 – 10 of 331
ATP5F1B
Tbio
Family:  Enzyme
Novelty:  0.01053177
p_int:  0.999458041
p_ni:  0.000541959
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
p_int:  0.998314656
p_ni:  0.001685344
Score:  0.993
Data Source:  BioPlex,STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
p_int:  0.954173426
p_ni:  0.045826574
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.944650499
p_ni:  0.055349501
Score:  0.999
Data Source:  BioPlex,STRINGDB
ATP5IF1
Tbio
Family:  Enzyme
Novelty:  0.01272196
p_int:  0.930592717
p_ni:  0.069407283
Score:  0.958
Data Source:  BioPlex,STRINGDB
ZFYVE27
Tbio
Novelty:  0.0563358
p_int:  0.880097237
p_ni:  0.119902763
Score:  0.818
Data Source:  BioPlex,STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.999
Data Source:  STRINGDB
ATP5PO
Tbio
Family:  Enzyme
Novelty:  0.01038964
Score:  0.999
Data Source:  STRINGDB
ATP5PD
Tbio
Family:  Enzyme
Novelty:  0.0730514
Score:  0.999
Data Source:  STRINGDB
ATP5F1E
Tbio
Family:  Enzyme
Novelty:  0.01870657
Score:  0.998
Data Source:  STRINGDB
Publication Statistics
PubMed Score  12.61

PubMed score by year
PubTator Score  1.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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