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Tclin
MAP2K2
Dual specificity mitogen-activated protein kinase kinase 2

Protein Summary
Description
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by Re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262948
  • ENSP00000262948
  • ENSG00000126934

Symbol
  • MEK2
  • MKK2
  • PRKMK2
  • CFC4
  • MEK2
  • MKK2
  • MAPKK2
  • PRKMK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
pathway
1
hub protein
0.98
chemical
0.95
biological process
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.41   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 1236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.41   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 1236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
60.6
monocyte count
1
1
1
15.7
lymphocyte count
1
1
1
15.7
leukocyte count
1
1
1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
60.6
monocyte count
1
15.7
lymphocyte count
1
15.7
leukocyte count
1
7.3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (241)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
Disease
Diseases of signal transduction
Gene Ontology Terms (38)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (229)
1 – 10 of 229
MAP2K1
Tclin
Family: Kinase
Novelty: 0.0005278
p_int: 0.999999978
p_ni: 2e-9
p_wrong: 2e-8
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
p_int: 0.999999838
p_ni: 1.62e-7
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
HSP90AA4P
Tdark
p_int: 0.999999217
p_ni: 7.77e-7
p_wrong: 6e-9
Data Source: BioPlex
HSP90AB3P
Tdark
p_int: 0.999994207
p_ni: 0.000004742
p_wrong: 0.000001051
Data Source: BioPlex
HSP90AB4P
Tdark
p_int: 0.999940075
p_ni: 0.000059924
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.999681043
p_ni: 0.000318956
p_wrong: 1e-9
Data Source: BioPlex
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.998578596
p_ni: 0.001421404
Score: 0.151
Data Source: BioPlex,STRINGDB
CNOT3
Tbio
Novelty: 0.02463568
p_int: 0.960986118
p_ni: 0.039013882
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.959266226
p_ni: 0.040733774
Score: 0.203
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
p_int: 0.833428024
p_ni: 0.166571976
Data Source: BioPlex
Publication Statistics
PubMed Score  120.41

PubMed score by year
PubTator Score  646.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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