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Tbio
TCF7
Transcription factor 7

Protein Summary
Description
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte dif ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342854
  • ENSP00000340347
  • ENSG00000081059
  • ENST00000378560
  • ENSP00000367822
  • ENST00000395023
  • ENSP00000378469
  • ENST00000518915
  • ENSP00000430179
  • ENST00000520958
  • ENSP00000429547

Symbol
  • TCF1
  • TCF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.88
transcription factor
0.82
biological process
0.81
protein domain
0.73
histone modification site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.36   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.36   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
72.4
eosinophil percentage of leukocytes
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
72.4
eosinophil percentage of leukocytes
1
36.5
Pathways (105)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Binding of TCF/LEF:CTNNB1 to target gene promoters
Reactome
Ca2+ pathway
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Binding of TCF/LEF:CTNNB1 to target gene promoters
Ca2+ pathway
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
Gene Ontology Terms (26)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (181)
1 – 10 of 181
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.986
Data Source: Reactome,STRINGDB
AXIN2
Tchem
Novelty: 0.00273189
Score: 0.963
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.958
Data Source: STRINGDB
NLK
Tchem
Family: Kinase
Novelty: 0.01512201
Score: 0.958
Data Source: STRINGDB
RUNX3
Tbio
Family: TF
Novelty: 0.00144472
Score: 0.957
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.953
Data Source: STRINGDB
TLE2
Tbio
Novelty: 0.03922169
Score: 0.953
Data Source: STRINGDB
TLE1
Tbio
Novelty: 0.00594261
Score: 0.952
Data Source: STRINGDB
APC
Tbio
Novelty: 0.00168376
Score: 0.948
Data Source: STRINGDB
SOX4
Tbio
Family: TF
Novelty: 0.00348137
Score: 0.946
Data Source: STRINGDB
Publication Statistics
PubMed Score  104.36

PubMed score by year
PubTator Score  129.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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