Tbio CHI3L1 Chitinase-3-like protein 1

Protein Summary

Description

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P36222
• B2R7B0
• P30923
• Q8IVA4
• Q96HI7

Gene Name

• CHI3L1

Ensembl ID

• ENST00000255409
• ENSP00000255409
• ENSG00000133048

Symbol

• GP39
• ASRT7
• GP-39
• YK-40
• YKL40
• CGP-39
• YKL-40
• YYL-40
• HC-gp39
• HCGP-3P
• hCGP-39

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.98
gene perturbation	0.96
biological process	0.91
protein domain	0.85
PubMedID	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1191.7   (req: < 5)

Gene RIFs: 533   (req: <= 3)

Antibodies: 406   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1191.7   (req: >= 5)

Gene RIFs: 533   (req: > 3)

Antibodies: 406   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0