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Tbio
PSMC2
26S proteasome regulatory subunit 7

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292644
  • ENSP00000292644
  • ENSG00000161057
  • ENST00000435765
  • ENSP00000391211

Symbol
  • MSS1
  • S7
  • MSS1
  • Nbla10058
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
biological process
0.98
transcription factor perturbation
0.94
molecular function
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.29   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.29   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (425)
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.996679183
p_ni:  0.003320817
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.994242843
p_ni:  0.005757157
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD5
Tbio
Family:  Enzyme
Novelty:  0.00070666
p_int:  0.993957128
p_ni:  0.006042872
Score:  0.995
Data Source:  BioPlex,STRINGDB
RAD21
Tbio
Novelty:  0.00270936
p_int:  0.99059563
p_ni:  0.008815382
p_wrong:  0.000588988
Score:  0.531
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.9899239
p_ni:  0.0100761
Score:  0.997
Data Source:  BioPlex,STRINGDB
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.987770507
p_ni:  0.012229493
Score:  0.989
Data Source:  BioPlex,STRINGDB
CCDC74B
Tdark
Novelty:  1.7435743
p_int:  0.98562142
p_ni:  0.01437858
Score:  0.821
Data Source:  BioPlex,STRINGDB
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
p_int:  0.982469189
p_ni:  0.017530811
Score:  0.999
Data Source:  BioPlex,STRINGDB
SMC3
Tbio
Novelty:  0.00474377
p_int:  0.982435708
p_ni:  0.017564292
Score:  0.755
Data Source:  BioPlex,STRINGDB
PSMC1
Tbio
Family:  Enzyme
Novelty:  0.04631888
p_int:  0.979934927
p_ni:  0.020065073
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (158)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 149
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1
74.3
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
74.3
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, ATPase 2
VGNC:4482
463632
Mouse
MGI:109555
19181
Rat
RGD:3428
25581
Dog
proteasome 26S subunit, ATPase 2
VGNC:45102
475896
Horse
proteasome 26S subunit, ATPase 2
VGNC:21950
100058456
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, ATPase 2
Mouse
Rat
Dog
proteasome 26S subunit, ATPase 2
Horse
proteasome 26S subunit, ATPase 2
Publication Statistics
PubMed Score 17.29
PubMed score by year
PubTator Score 14.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title