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Tclin
KDR
Vascular endothelial growth factor receptor 2

Protein Summary
Description
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263923
  • ENSP00000263923
  • ENSG00000128052
  • ENST00000645273
  • ENSP00000495159

Symbol
  • FLK1
  • VEGFR2
  • FLK1
  • CD309
  • VEGFR
  • VEGFR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
biological term
0.99
PubMedID
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7151.11   (req: < 5)
Gene RIFs: 899   (req: <= 3)
Antibodies: 3201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7151.11   (req: >= 5)
Gene RIFs: 899   (req: > 3)
Antibodies: 3201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2625
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 17