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Tclin
KDR
Vascular endothelial growth factor receptor 2

Protein Summary
Description
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of p ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263923
  • ENSP00000263923
  • ENSG00000128052
  • ENST00000645273
  • ENSP00000495159

Symbol
  • FLK1
  • VEGFR2
  • FLK1
  • CD309
  • VEGFR
  • VEGFR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
biological term
0.99
PubMedID
0.98


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6254.06   (req: < 5)
Gene RIFs: 775   (req: <= 3)
Antibodies: 3201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6254.06   (req: >= 5)
Gene RIFs: 775   (req: > 3)
Antibodies: 3201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2258
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 15
Approved Drugs (15)
1 – 10 of 15
sunitinib
chemical structure image
nintedanib
chemical structure image
sorafenib
chemical structure image
ponatinib
chemical structure image
pazopanib
chemical structure image
axitinib
chemical structure image
cabozantinib
chemical structure image
vandetanib
chemical structure image
pexidartinib
chemical structure image
lenvatinib
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
15.9
forced expiratory volume
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
15.9
forced expiratory volume
1
1.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinase insert domain receptor
VGNC:755
461315
Macaque
kinase insert domain receptor
698293
Mouse
MGI:96683
16542
Rat
RGD:2965
25589
Dog
kinase insert domain receptor
VGNC:42331
482154
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinase insert domain receptor
Macaque
kinase insert domain receptor
Mouse
Rat
Dog
kinase insert domain receptor
Protein Structure (52 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35968-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 52
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (48)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Reactome
Neurophilin interactions with VEGF and VEGFR
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Integrin cell surface interactions
Neurophilin interactions with VEGF and VEGFR
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (65)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (514)
1 – 10 of 514
VEGFC
Tbio
Novelty: 0.00077508
Score: 0.999
Data Source: Reactome,STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.999
Data Source: Reactome,STRINGDB
NRP1
Tchem
Novelty: 0.00153628
Score: 0.998
Data Source: Reactome,STRINGDB
CDH5
Tbio
Novelty: 0.00072649
Score: 0.997
Data Source: STRINGDB
VEGFD
Tbio
Novelty: 0.00233128
Score: 0.995
Data Source: Reactome,STRINGDB
FLT1
Tclin
Family: Kinase
Novelty: 0.00039648
Score: 0.988
Data Source: STRINGDB
PGF
Tclin
Novelty: 0.00061576
Score: 0.984
Data Source: STRINGDB
PECAM1
Tbio
Novelty: 0.00013373
Score: 0.984
Data Source: STRINGDB
NRP2
Tbio
Novelty: 0.00764179
Score: 0.983
Data Source: STRINGDB
NOS3
Tchem
Family: Enzyme
Novelty: 0.00012407
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  6254.06

PubMed score by year
PubTator Score  4316.96

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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