FLT4
Vascular endothelial growth factor receptor 3
Protein Summary
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosph ...more
- ENST00000261937
- ENSP00000261937
- ENSG00000037280
- ENST00000393347
- ENSP00000377016
- VEGFR3
- PCL
- FLT-4
- FLT41
- LMPH1A
- LMPHM1
- VEGFR3
- VEGFR-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
biological process | 0.87 | ||
PubMedID | 0.77 | ||
biological term | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 736.76 (req: < 5)
Gene RIFs: 183 (req: <= 3)
Antibodies: 968 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 736.76 (req: >= 5)
Gene RIFs: 183 (req: > 3)
Antibodies: 968 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 34
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 215
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 8
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (8)
Active Ligands (215)
Protein-Protein Interactions (203)
CLEC4A
Novelty: 0.01821643
p_int: 0.999517955
p_ni: 0.000482043
p_wrong: 2e-9
Score: 0.263
Data Source: BioPlex,STRINGDB
LGALS8
Novelty: 0.00623836
p_int: 0.997814357
p_ni: 0.002185643
Score: 0.236
Data Source: BioPlex,STRINGDB
PTGER3
Family: GPCR
Novelty: 0.0012681
p_int: 0.982596757
p_ni: 0.017403239
p_wrong: 3e-9
Score: 0.192
Data Source: BioPlex,STRINGDB
NPY2R
Family: GPCR
Novelty: 0.01177255
p_int: 0.925277448
p_ni: 0.074722552
Data Source: BioPlex
LPCAT2
Family: Enzyme
Novelty: 0.02794035
p_int: 0.823472772
p_ni: 0.176517704
p_wrong: 0.000009524
Data Source: BioPlex
ACVR2B
Family: Kinase
Novelty: 0.00555742
p_int: 0.820444269
p_ni: 0.179417569
p_wrong: 0.000138161
Data Source: BioPlex
LGALS3
Novelty: 0.00032754
p_int: 0.77906112
p_ni: 0.22093888
Score: 0.231
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (166)
Reactome (8)
KEGG (7)
PathwayCommons (7)
WikiPathways (144)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | NOTCH4 Intracellular Domain Regulates Transcription | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by NOTCH | ||||
Reactome | Signaling by NOTCH4 | ||||
Reactome | Signaling by Receptor Tyrosine Kinases | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
NOTCH4 Intracellular Domain Regulates Transcription | ||||
Signal Transduction | ||||
Signaling by NOTCH | ||||
Signaling by NOTCH4 | ||||
Signaling by Receptor Tyrosine Kinases | ||||
Viral Interactions (0)
Gene Ontology Terms (40)
Functions (8)
Components (6)
Processes (26)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 63.1 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 49.5 | |||||
serum albumin measurement | 1 | 1 | 1 | 44.2 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 63.1 | |||||
mean reticulocyte volume | 1 | 49.5 | |||||
serum albumin measurement | 1 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | fms related tyrosine kinase 4 | VGNC:6876 | 462339 | |||||
Macaque | fms related tyrosine kinase 4 | 716412 | ||||||
Mouse | MGI:95561 | 14257 | ||||||
Rat | RGD:621737 | 114110 | ||||||
Dog | fms related tyrosine kinase 4 | VGNC:40910 | 481464 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | fms related tyrosine kinase 4 | |||||
Macaque | fms related tyrosine kinase 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | fms related tyrosine kinase 4 | |||||
Publication Statistics
PubMed Score 736.76
PubMed score by year
PubTator Score 699.69
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (223)
GeneRif Annotations (183)
Items per page:
0 of 0
PMID | Year | Title |
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