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Tclin
FLT4
Vascular endothelial growth factor receptor 3

Protein Summary
Description
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261937
  • ENSP00000261937
  • ENSG00000037280
  • ENST00000393347
  • ENSP00000377016

Symbol
  • VEGFR3
  • PCL
  • FLT-4
  • FLT41
  • LMPH1A
  • LMPHM1
  • VEGFR3
  • VEGFR-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
biological process
0.87
PubMedID
0.77
biological term
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 812.85   (req: < 5)
Gene RIFs: 183   (req: <= 3)
Antibodies: 968   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 812.85   (req: >= 5)
Gene RIFs: 183   (req: > 3)
Antibodies: 968   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 217
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8