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Tclin
FLT4
Vascular endothelial growth factor receptor 3

Protein Summary
Description
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261937
  • ENSP00000261937
  • ENSG00000037280
  • ENST00000393347
  • ENSP00000377016

Symbol
  • VEGFR3
  • PCL
  • FLT-4
  • FLT41
  • LMPH1A
  • LMPHM1
  • VEGFR3
  • VEGFR-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
biological process
0.87
PubMedID
0.77
biological term
0.72


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 716.47   (req: < 5)
Gene RIFs: 183   (req: <= 3)
Antibodies: 968   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 716.47   (req: >= 5)
Gene RIFs: 183   (req: > 3)
Antibodies: 968   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 139
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fms related tyrosine kinase 4
VGNC:6876
462339
Macaque
fms related tyrosine kinase 4
716412
Mouse
MGI:95561
14257
Rat
RGD:621737
114110
Dog
fms related tyrosine kinase 4
VGNC:40910
481464
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fms related tyrosine kinase 4
Macaque
fms related tyrosine kinase 4
Mouse
Rat
Dog
fms related tyrosine kinase 4
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35916-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (166)
NOTCH4 Intracellular Domain Regulates Transcription (R-HSA-9013695)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
NOTCH4 Intracellular Domain Regulates Transcription
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Reactome
Signaling by NOTCH4
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
NOTCH4 Intracellular Domain Regulates Transcription
Signal Transduction
Signaling by NOTCH
Signaling by NOTCH4
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (40)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (203)
1 – 10 of 203
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.999517955
p_ni: 0.000482043
p_wrong: 2e-9
Score: 0.263
Data Source: BioPlex,STRINGDB
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.997814357
p_ni: 0.002185643
Score: 0.236
Data Source: BioPlex,STRINGDB
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
p_int: 0.982596757
p_ni: 0.017403239
p_wrong: 3e-9
Score: 0.192
Data Source: BioPlex,STRINGDB
MAS1
Tchem
Family: GPCR
Novelty: 0.0089712
p_int: 0.944953846
p_ni: 0.055046154
Data Source: BioPlex
PCDHGB1
Tdark
Novelty: 0.60440805
p_int: 0.944579863
p_ni: 0.055420137
Data Source: BioPlex
NPY2R
Tchem
Family: GPCR
Novelty: 0.01177255
p_int: 0.925277448
p_ni: 0.074722552
Data Source: BioPlex
TMEM52B
Tdark
Novelty: 1.55824039
p_int: 0.896526996
p_ni: 0.103473004
Data Source: BioPlex
LPCAT2
Tbio
Family: Enzyme
Novelty: 0.02794035
p_int: 0.823472772
p_ni: 0.176517704
p_wrong: 0.000009524
Data Source: BioPlex
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.820444269
p_ni: 0.179417569
p_wrong: 0.000138161
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.77906112
p_ni: 0.22093888
Score: 0.231
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  716.47

PubMed score by year
PubTator Score  699.69

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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