FLT4
Vascular endothelial growth factor receptor 3
Protein Classes
Protein Summary
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosph ...more
- ENST00000261937
- ENSP00000261937
- ENSG00000037280
- ENST00000393347
- ENSP00000377016
- VEGFR3
- PCL
- FLT-4
- FLT41
- LMPH1A
- LMPHM1
- VEGFR3
- VEGFR-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
biological process | 0.87 | ||
PubMedID | 0.77 | ||
biological term | 0.72 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 716.47 (req: < 5)
Gene RIFs: 183 (req: <= 3)
Antibodies: 968 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 716.47 (req: >= 5)
Gene RIFs: 183 (req: > 3)
Antibodies: 968 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 34
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 139
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 7
Approved Drugs (7)
1 – 7 of 7
Active Ligands (139)
1 – 10 of 139
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (166)
Reactome (8)
KEGG (7)
PathwayCommons (7)
WikiPathways (144)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | NOTCH4 Intracellular Domain Regulates Transcription | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by NOTCH | ||||
Reactome | Signaling by NOTCH4 | ||||
Reactome | Signaling by Receptor Tyrosine Kinases | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
NOTCH4 Intracellular Domain Regulates Transcription | ||||
Signal Transduction | ||||
Signaling by NOTCH | ||||
Signaling by NOTCH4 | ||||
Signaling by Receptor Tyrosine Kinases | ||||
Gene Ontology Terms (40)
Functions (8)
Components (6)
Processes (26)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (203)
1 – 10 of 203
CLEC4A
Novelty: 0.01821643
p_int: 0.999517955
p_ni: 0.000482043
p_wrong: 2e-9
Score: 0.263
Data Source: BioPlex,STRINGDB
LGALS8
Novelty: 0.00623836
p_int: 0.997814357
p_ni: 0.002185643
Score: 0.236
Data Source: BioPlex,STRINGDB
PTGER3
Family: GPCR
Novelty: 0.0012681
p_int: 0.982596757
p_ni: 0.017403239
p_wrong: 3e-9
Score: 0.192
Data Source: BioPlex,STRINGDB
MAS1
Family: GPCR
Novelty: 0.0089712
p_int: 0.944953846
p_ni: 0.055046154
Data Source: BioPlex
PCDHGB1
Novelty: 0.60440805
p_int: 0.944579863
p_ni: 0.055420137
Data Source: BioPlex
NPY2R
Family: GPCR
Novelty: 0.01177255
p_int: 0.925277448
p_ni: 0.074722552
Data Source: BioPlex
TMEM52B
Novelty: 1.55824039
p_int: 0.896526996
p_ni: 0.103473004
Data Source: BioPlex
LPCAT2
Family: Enzyme
Novelty: 0.02794035
p_int: 0.823472772
p_ni: 0.176517704
p_wrong: 0.000009524
Data Source: BioPlex
ACVR2B
Family: Kinase
Novelty: 0.00555742
p_int: 0.820444269
p_ni: 0.179417569
p_wrong: 0.000138161
Data Source: BioPlex
LGALS3
Novelty: 0.00032754
p_int: 0.77906112
p_ni: 0.22093888
Score: 0.231
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 716.47
PubMed score by year
PubTator Score 699.69
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
Find similar targets by:
UniProt Keyword