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Tbio
IGFALS
Insulin-like growth factor-binding protein complex acid labile subunit

Protein Classes
Protein Summary
Description
Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion. The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215539
  • ENSP00000215539
  • ENSG00000099769
  • ENST00000415638
  • ENSP00000416683

Symbol
  • ALS
  • ALS
  • ACLSD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.66
cell line
0.6
protein domain
0.58
gene perturbation
0.55
transcription factor
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.12   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.12   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
79.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
79.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein acid labile subunit
VGNC:51581
467869
Macaque
insulin like growth factor binding protein acid labile subunit
722493
Mouse
MGI:107973
16005
Rat
RGD:68429
79438
Dog
insulin like growth factor binding protein acid labile subunit
VGNC:54036
490069
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin like growth factor binding protein acid labile subunit
Macaque
insulin like growth factor binding protein acid labile subunit
Mouse
Rat
Dog
insulin like growth factor binding protein acid labile subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35858-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (82)
1 – 10 of 82
IGFBP3
Tchem
Novelty: 0.0003776
Score: 0.978
Data Source: Reactome,STRINGDB
IGF1
Tbio
Novelty: 0.00003878
Score: 0.976
Data Source: Reactome,STRINGDB
IGFBP5
Tchem
Novelty: 0.0025185
Score: 0.969
Data Source: Reactome,STRINGDB
IGF2
Tbio
Novelty: 0.00021277
Score: 0.944
Data Source: Reactome,STRINGDB
PAPPA2
Tbio
Novelty: 0.02135603
Score: 0.917
Data Source: Reactome,STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.914
Data Source: Reactome,STRINGDB
PAPPA
Tbio
Novelty: 0.00062817
Score: 0.913
Data Source: Reactome,STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.913
Data Source: Reactome,STRINGDB
CTSG
Tchem
Family: Enzyme
Novelty: 0.00102052
Score: 0.912
Data Source: Reactome,STRINGDB
KLK1
Tchem
Family: Enzyme
Novelty: 0.00190157
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.12

PubMed score by year
PubTator Score  26.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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