Protein Summary
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
- ENST00000237858
- ENSP00000237858
- ENSG00000173221
- ENST00000379979
- ENSP00000369314
- ENST00000505427
- ENSP00000427353
- ENST00000508780
- ENSP00000422708
- ENST00000512469
- ENSP00000424636
- GRX
- GRX
- GRX1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
PubMedID | 0.99 | ||
kinase perturbation | 0.96 | ||
small molecule perturbation | 0.96 | ||
disease perturbation | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1099.81 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 249 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1099.81 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 249 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0