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Tbio
MYH11
Myosin-11

Protein Summary
Description
Muscle contraction. The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300036
  • ENSP00000300036
  • ENSG00000133392
  • ENST00000396324
  • ENSP00000379616
  • ENST00000452625
  • ENSP00000407821
  • ENST00000576790
  • ENSP00000458731
  • ENST00000612165
  • ENSP00000478092
  • ENSG00000276480
  • ENST00000616422
  • ENSP00000478816
  • ENST00000621545
  • ENSP00000478109
  • ENST00000634050
  • ENSP00000488461

Symbol
  • KIAA0866
  • AAT4
  • FAA4
  • SMHC
  • SMMHC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
kinase perturbation
0.97
protein domain
0.92
cellular component
0.78
protein complex
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 681.2   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 655   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 681.2   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 655   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin aging measurement
1
1
1
43.6
skin aging measurement
1
1
1
43.6
inflammatory biomarker measurement
1
1
0
46.3
23.5
inflammatory biomarker measurement
1
1
0
46.3
23.5
intelligence
1
1
1
13.7
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
skin aging measurement
1
43.6
skin aging measurement
1
43.6
inflammatory biomarker measurement
0
46.3
23.5
inflammatory biomarker measurement
0
46.3
23.5
intelligence
1
13.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 11
VGNC:51223
453949
Macaque
myosin heavy chain 11
713882
Mouse
MGI:102643
17880
Dog
myosin heavy chain 11
VGNC:43536
479836
Horse
myosin heavy chain 11
VGNC:20478
100050346
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 11
Macaque
myosin heavy chain 11
Mouse
Dog
myosin heavy chain 11
Horse
myosin heavy chain 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35749-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHA-mediated growth cone collapse
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
Muscle contraction
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (217)
1 – 10 of 217
MYL6
Tbio
Novelty: 0.00594485
p_int: 0.999999963
p_ni: 7e-9
p_wrong: 3.1e-8
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
PSMD3
Tbio
Family: Enzyme
Novelty: 0.03106272
p_int: 0.999999222
p_ni: 7.77e-7
Data Source: BioPlex
RWDD2B
Tdark
Novelty: 0.42452529
p_int: 0.999996185
p_ni: 0.000003809
p_wrong: 6e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
MPP1
Tbio
Novelty: 0.08674817
p_int: 0.999982472
p_ni: 0.000017521
p_wrong: 8e-9
Score: 0.41
Data Source: BioPlex,STRINGDB
OVCA2
Tbio
Novelty: 0.1210116
p_int: 0.999944126
p_ni: 0.000032861
p_wrong: 0.000023013
Score: 0.548
Data Source: BioPlex,STRINGDB
GDF9
Tbio
Novelty: 0.00258351
p_int: 0.999937249
p_ni: 0.000029226
p_wrong: 0.000033526
Score: 0.227
Data Source: BioPlex,STRINGDB
SLC9A8
Tbio
Family: Transporter
Novelty: 0.03305341
p_int: 0.997023228
p_ni: 0.000179549
p_wrong: 0.002797223
Data Source: BioPlex
ACTA2
Tbio
Novelty: 0.00199354
Score: 0.993
Data Source: STRINGDB
ACTG2
Tbio
Novelty: 0.00304944
Score: 0.986
Data Source: STRINGDB
MYL12B
Tbio
Novelty: 0.00999083
Score: 0.985
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  681.20

PubMed score by year
PubTator Score  215.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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