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Tbio
SOX6
Transcription factor SOX-6

Protein Summary
Description
Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation. This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316399
  • ENSP00000324948
  • ENSG00000110693
  • ENST00000396356
  • ENSP00000379644
  • ENST00000527619
  • ENSP00000434455
  • ENST00000528252
  • ENSP00000432134
  • ENST00000528429
  • ENSP00000433233

Symbol
  • SOXD
  • HSSOX6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
biological process
0.9
disease
0.72
PubMedID
0.72
transcription factor
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.27   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.27   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
SOX5
Tbio
Family:  TF
Novelty:  0.00623121
p_int:  1
Score:  0.568
Data Source:  BioPlex,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.969
Data Source:  STRINGDB
LHX6
Tbio
Family:  TF
Novelty:  0.01603143
Score:  0.766
Data Source:  STRINGDB
PURB
Tbio
Novelty:  0.02303518
Score:  0.748
Data Source:  STRINGDB
CTBP2
Tchem
Novelty:  0.00538964
Score:  0.731
Data Source:  STRINGDB
COL2A1
Tbio
Novelty:  0.0011102
Score:  0.717
Data Source:  STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.715
Data Source:  STRINGDB
CENPK
Tbio
Novelty:  0.04316098
Score:  0.7
Data Source:  STRINGDB
NEUROG1
Tbio
Family:  TF
Novelty:  0.00494095
Score:  0.699
Data Source:  STRINGDB
LHX8
Tbio
Family:  TF
Novelty:  0.01815234
Score:  0.671
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (48)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
14
20
96.9
reticulocyte count
6
6
11
96.5
red blood cell distribution width
4
2
4
95.8
mean corpuscular volume
2
3
3
94.6
mean corpuscular hemoglobin concentration
2
2
2
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
20
96.9
reticulocyte count
11
96.5
red blood cell distribution width
4
95.8
mean corpuscular volume
3
94.6
mean corpuscular hemoglobin concentration
2
93.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SRY-box 6
VGNC:1000
466449
Macaque
SRY-box 6
697831
Mouse
MGI:98368
20679
Rat
RGD:1309000
293165
Dog
SRY-box 6
VGNC:46682
476871
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SRY-box 6
Macaque
SRY-box 6
Mouse
Rat
Dog
SRY-box 6
Publication Statistics
PubMed Score 226.27
PubMed score by year
PubTator Score 74.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title