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Tbio
HNF1B
Hepatocyte nuclear factor 1-beta

Protein Summary
Description
Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610754
  • ENSP00000484591
  • ENSG00000276194
  • ENST00000617811
  • ENSP00000480291
  • ENSG00000275410
  • ENST00000621123
  • ENSP00000482711
  • ENST00000633792
  • ENSP00000488080

Symbol
  • TCF2
  • FJHN
  • HNF2
  • LFB3
  • TCF2
  • HPC11
  • LF-B3
  • MODY5
  • TCF-2
  • VHNF1
  • HNF-1B
  • HNF1beta
  • HNF-1-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
trait
0.99
biological term
0.88
protein domain
0.85
phenotype
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 510.35   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 481   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 510.35   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (74)
Items per page:
1 – 5 of 74
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
13
6
0
1.2
99.1
13
6
0
1.2
99.1
11
7
4
1.1
98.5
11
7
4
1.1
98.5
2
4
0
1.1
96.7
Items per page:
1 – 5 of 74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
99.1
0
1.2
99.1
4
1.1
98.5
4
1.1
98.5
0
1.1
96.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
HNF1 homeobox B
714540
Mouse
MGI:98505
21410
Rat
RGD:3830
25640
Dog
HNF1 homeobox B
VGNC:41724
610402
Horse
HNF1 homeobox B
VGNC:18818
100057769
Species
Name
OMA
EggNOG
Inparanoid
Macaque
HNF1 homeobox B
Mouse
Rat
Dog
HNF1 homeobox B
Horse
HNF1 homeobox B
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35680-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of beta-cell development
Reactome
Regulation of gene expression in early pancreatic precursor cells
Reactome
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of beta-cell development
Regulation of gene expression in early pancreatic precursor cells
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Gene Ontology Terms (45)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (71)
1 – 10 of 71
ONECUT1
Tbio
Family:  TF
Novelty:  0.0086548
Score:  0.97
Data Source:  STRINGDB
PTF1A
Tbio
Family:  TF
Novelty:  0.00593299
Score:  0.947
Data Source:  STRINGDB
PCBD1
Tbio
Family:  Enzyme
Novelty:  0.01564376
Score:  0.902
Data Source:  STRINGDB
HNF4A
Tchem
Family:  NR
Novelty:  0.00041409
Score:  0.856
Data Source:  STRINGDB
PCBD2
Tbio
Family:  Enzyme
Novelty:  0.11676823
Score:  0.747
Data Source:  STRINGDB
DBP
Tbio
Family:  TF
Novelty:  0.02264853
Score:  0.681
Data Source:  STRINGDB
SOX9
Tbio
Family:  TF
Novelty:  0.00047439
Score:  0.675
Data Source:  STRINGDB
PDX1
Tbio
Family:  TF
Novelty:  0.00232117
Score:  0.673
Data Source:  STRINGDB
KIF12
Tdark
Novelty:  0.14893428
Score:  0.672
Data Source:  STRINGDB
CDKAL1
Tbio
Family:  Enzyme
Novelty:  0.01013607
Score:  0.64
Data Source:  STRINGDB
Publication Statistics
PubMed Score  510.35

PubMed score by year
PubTator Score  413.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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