Tbio ATP7B Copper-transporting ATPase 2

Protein Summary

Description

Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload. This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35670
• Q16318
• Q16319
• Q4U3V3
• Q59FJ9
• Q5T7X7

Gene Name

• ATP7B

Ensembl ID

• ENST00000242839
• ENSP00000242839
• ENSG00000123191
• ENST00000344297
• ENSP00000342559
• ENST00000400366
• ENSP00000383217

Symbol

• PWD
• WC1
• WND
• WD
• PWD
• WC1
• WND

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.99
transcription factor perturbation	0.8
histone modification site profile	0.74
cellular component	0.73

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Copper-transporting Atpase 2

Protein / Transporter / Cation Transporter / Copper-transporting Atpase 2

Protein / Hydrolase / Copper-transporting Atpase 2

DTO Classes

Protein / Transporter / P-type Atpases / Cu+-atpases / Copper-transporting Atpase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1066.25   (req: < 5)

Gene RIFs: 287   (req: <= 3)

Antibodies: 465   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1066.25   (req: >= 5)

Gene RIFs: 287   (req: > 3)

Antibodies: 465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0