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Tbio
DEK
Protein DEK

Protein Summary
Description
Involved in chromatin organization. This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244776
  • ENSP00000244776
  • ENSG00000124795
  • ENST00000397239
  • ENSP00000380414

Symbol
  • D6S231E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
kinase perturbation
0.88
transcription factor binding site profile
0.81
microRNA
0.75
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.23   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.23   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (188)
UPF1
Tbio
Novelty:  0.00311006
Score:  0.995
Data Source:  STRINGDB
BAZ1B
Tbio
Family:  Epigenetic
Novelty:  0.02374034
Score:  0.953
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.948
Data Source:  STRINGDB
SMARCA5
Tbio
Novelty:  0.00518484
Score:  0.948
Data Source:  STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.947
Data Source:  STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
Score:  0.947
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.946
Data Source:  STRINGDB
TFAP2A
Tbio
Family:  TF
Novelty:  0.00235655
Score:  0.941
Data Source:  Reactome,STRINGDB
SF3B1
Tbio
Novelty:  0.0128965
Score:  0.933
Data Source:  STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
Score:  0.932
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Developmental Biology
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Developmental Biology
Epigenetic regulation of gene expression
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to mercaptopurine
1
1
0
7.7
85.5
thiopurine methyltransferase activity measurement
1
1
0
7.7
85.5
2
1
0
1.1
77
1
1
0
5.6
21.5
age at onset
1
1
0
5.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to mercaptopurine
0
7.7
85.5
thiopurine methyltransferase activity measurement
0
7.7
85.5
0
1.1
77
0
5.6
21.5
age at onset
0
5.6
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEK proto-oncogene
VGNC:10022
462460
Mouse
MGI:1926209
110052
Rat
RGD:1303246
306817
Dog
DEK proto-oncogene
VGNC:49852
610538
Horse
DEK proto-oncogene
VGNC:17119
100066265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEK proto-oncogene
Mouse
Rat
Dog
DEK proto-oncogene
Horse
DEK proto-oncogene
Publication Statistics
PubMed Score 308.23
PubMed score by year
PubTator Score 163.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title