Tbio NUP214 Nuclear pore complex protein Nup214

Protein Summary

Description

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• P35658
• A6NFQ0
• Q15010
• Q3KQZ0
• Q5JUP7
• Q75R47
• Q86XD3

Gene Name

• NUP214

Ensembl ID

• ENST00000359428
• ENSP00000352400
• ENSG00000126883
• ENST00000411637
• ENSP00000396576

Symbol

• CAIN
• CAN
• KIAA0023
• CAN
• CAIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.9
histone modification site profile	0.88
transcription factor binding site profile	0.85
biological process	0.75
tissue sample	0.74

Protein Classes

PANTHER Classes

Protein / Structural Protein / Nuclear Pore Complex Protein Nup214

Protein / Nucleic Acid Binding / Rna Binding Protein / Nuclear Pore Complex Protein Nup214

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Nuclear Pore Complex Protein Nup214

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.02   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.02   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (275)

Explore Interacting Targets

1 – 10 of 275

• See Interactions on String-DB

NUP88

Tbio

Novelty:  0.02483503

p_int:  0.999968251

p_ni:  0.000031749

Score:  0.999

Data Source:  BioPlex,STRINGDB

NUP62

Tbio

Novelty:  0.01432724

p_int:  0.999853657

p_ni:  0.000146344

Score:  0.999

Data Source:  BioPlex,STRINGDB

RAN

Tchem

Family:  Enzyme

Novelty:  0.00160888

p_int:  0.997033107

p_ni:  0.002966893

Score:  0.971

Data Source:  BioPlex,STRINGDB

NXF1

Tbio

Novelty:  0.00642439

p_int:  0.995678293

p_ni:  0.004321707

Score:  0.991

Data Source:  BioPlex,STRINGDB

DDX19A

Tdark

Family:  Enzyme

Novelty:  0.54074082

p_int:  0.994065716

p_ni:  0.005934284

Score:  0.945

Data Source:  BioPlex,STRINGDB

G3BP2

Tbio

Family:  Enzyme

Novelty:  0.04786241

p_int:  0.991794216

p_ni:  0.008205784

Score:  0.829

Data Source:  BioPlex,STRINGDB

NXF2

Tbio

Novelty:  0.04733504

p_int:  0.962150727

p_ni:  0.037849273

Score:  0.871

Data Source:  BioPlex,STRINGDB

FXR2

Tbio

Family:  Epigenetic

Novelty:  0.0253623

p_int:  0.936939963

p_ni:  0.063060037

Score:  0.195

Data Source:  BioPlex,STRINGDB

EMILIN1

Tbio

Novelty:  0.02550566

p_int:  0.889380711

p_ni:  0.110619289

Data Source:  BioPlex

SERPINB2

Tbio

Novelty:  0.00204345

p_int:  0.77011958

p_ni:  0.22988042

Score:  0.157

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (83)

Reactome (70)

KEGG (1)

PathwayCommons (7)

WikiPathways (5)

Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 70

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cellular response to heat stress	100 targets	R-HSA-3371556
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cellular response to heat stress	100 targets	R-HSA-3371556
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (3)

Components (7)

Processes (8)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
nuclear export signal receptor activity	Inferred from Direct Assay (IDA)	GO_Central
nuclear localization sequence binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of nuclear pore	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	1	1	1		69.5
oral cavity cancer	EFO_0005570	1	1	0	1.3	21.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
balding measurement	EFO_0007825	1		69.5
oral cavity cancer	EFO_0005570	0	1.3	21.5

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Chromosomal rearrangement
Coiled coil
Complete proteome
Glycoprotein
Isopeptide bond
mRNA transport
Nuclear pore complex

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
oral cavity cancer

MGI Phenotype Find Similar Targets

No Header	No Header
embryo phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 214kDa	VGNC:13926	464807
Macaque	nucleoporin 214		722421
Mouse	nucleoporin 214	MGI:1095411	227720
Dog	nucleoporin 214	VGNC:44052	608534
Horse	nucleoporin 214	VGNC:20967	100069634

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nucleoporin 214kDa
Macaque	nucleoporin 214
Mouse	nucleoporin 214
Dog	nucleoporin 214
Horse	nucleoporin 214

Publication Statistics

PubMed Score 101.02

PubMed score by year

Reset Zoom

PubTator Score 85.04

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (76)

GeneRif Annotations (42)

Items per page:

10

0 of 0

PMID	Year	Title