Tbio NUP214 Nuclear pore complex protein Nup214

Protein Summary

Description

May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• P35658
• A6NFQ0
• Q15010
• Q3KQZ0
• Q5JUP7
• Q75R47
• Q86XD3

Gene Name

• NUP214

Ensembl ID

• ENST00000359428
• ENSP00000352400
• ENSG00000126883
• ENST00000411637
• ENSP00000396576

Symbol

• CAIN
• CAN
• KIAA0023
• CAN
• CAIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.9
histone modification site profile	0.88
transcription factor binding site profile	0.85
biological process	0.75
tissue sample	0.74

Protein Classes

PANTHER Classes

Protein / Structural Protein / Nuclear Pore Complex Protein Nup214

Protein / Nucleic Acid Binding / Rna Binding Protein / Nuclear Pore Complex Protein Nup214

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Nuclear Pore Complex Protein Nup214

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.91   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.91   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0