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Tbio
NUP214
Nuclear pore complex protein Nup214

Protein Summary
Description
May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359428
  • ENSP00000352400
  • ENSG00000126883
  • ENST00000411637
  • ENSP00000396576

Symbol
  • CAIN
  • CAN
  • KIAA0023
  • CAN
  • CAIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.9
histone modification site profile
0.88
transcription factor binding site profile
0.85
biological process
0.75
tissue sample
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.02   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.02   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (275)
NUP88
Tbio
Novelty:  0.02483503
p_int:  0.999968251
p_ni:  0.000031749
Score:  0.999
Data Source:  BioPlex,STRINGDB
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.999853657
p_ni:  0.000146344
Score:  0.999
Data Source:  BioPlex,STRINGDB
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
p_int:  0.997033107
p_ni:  0.002966893
Score:  0.971
Data Source:  BioPlex,STRINGDB
NXF1
Tbio
Novelty:  0.00642439
p_int:  0.995678293
p_ni:  0.004321707
Score:  0.991
Data Source:  BioPlex,STRINGDB
DDX19A
Tdark
Family:  Enzyme
Novelty:  0.54074082
p_int:  0.994065716
p_ni:  0.005934284
Score:  0.945
Data Source:  BioPlex,STRINGDB
G3BP2
Tbio
Family:  Enzyme
Novelty:  0.04786241
p_int:  0.991794216
p_ni:  0.008205784
Score:  0.829
Data Source:  BioPlex,STRINGDB
NXF2
Tbio
Novelty:  0.04733504
p_int:  0.962150727
p_ni:  0.037849273
Score:  0.871
Data Source:  BioPlex,STRINGDB
FXR2
Tbio
Family:  Epigenetic
Novelty:  0.0253623
p_int:  0.936939963
p_ni:  0.063060037
Score:  0.195
Data Source:  BioPlex,STRINGDB
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.889380711
p_ni:  0.110619289
Data Source:  BioPlex
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.77011958
p_ni:  0.22988042
Score:  0.157
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (83)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
69.5
1
1
0
1.3
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
69.5
0
1.3
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 214kDa
VGNC:13926
464807
Macaque
nucleoporin 214
722421
Mouse
MGI:1095411
227720
Dog
nucleoporin 214
VGNC:44052
608534
Horse
nucleoporin 214
VGNC:20967
100069634
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleoporin 214kDa
Macaque
nucleoporin 214
Mouse
Dog
nucleoporin 214
Horse
nucleoporin 214
Publication Statistics
PubMed Score 101.02
PubMed score by year
PubTator Score 85.04
PubTator score by year
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Related Publications
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PMID
Year
Title