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Tchem
DDIT3
DNA damage-inducible transcript 3 protein

Protein Summary
Description
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346473
  • ENSP00000340671
  • ENSG00000175197
  • ENST00000547303
  • ENSP00000447188
  • ENST00000551116
  • ENSP00000448665
  • ENST00000552740
  • ENSP00000447803
  • ENST00000623876
  • ENSP00000494844

Symbol
  • CHOP
  • CHOP10
  • GADD153
  • CHOP
  • CEBPZ
  • CHOP10
  • CHOP-10
  • GADD153
  • AltDDIT3
  • C/EBPzeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
molecular function
0.98
transcription factor binding site profile
0.97
small molecule perturbation
0.96


Related Tools
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 915.06   (req: < 5)
Gene RIFs: 183   (req: <= 3)
Antibodies: 895   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 915.06   (req: >= 5)
Gene RIFs: 183   (req: > 3)
Antibodies: 895   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA damage inducible transcript 3
VGNC:12914
452017
Macaque
DNA damage inducible transcript 3
714901
Mouse
MGI:109247
13198
Rat
RGD:62391
29467
Dog
DNA damage inducible transcript 3
VGNC:39836
607439
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA damage inducible transcript 3
Macaque
DNA damage inducible transcript 3
Mouse
Rat
Dog
DNA damage inducible transcript 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35638-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
ATF6 (ATF6-alpha) activates chaperone genes
Reactome
ATF6 (ATF6-alpha) activates chaperones
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of cell death genes
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
ATF6 (ATF6-alpha) activates chaperones
FOXO-mediated transcription
FOXO-mediated transcription of cell death genes
Gene Ontology Terms (62)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Genetic Interaction (IGI)
ParkinsonsUK-UCL
Protein-Protein Interactions (208)
1 – 10 of 208
ATF4
Tbio
Family: TF
Novelty: 0.00253408
Score: 0.996
Data Source: STRINGDB
ATF6
Tbio
Family: TF
Novelty: 0.00149266
Score: 0.989
Data Source: STRINGDB
XBP1
Tchem
Family: TF
Novelty: 0.00095584
Score: 0.975
Data Source: STRINGDB
ATF3
Tbio
Family: TF
Novelty: 0.00164508
Score: 0.973
Data Source: STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.958
Data Source: STRINGDB
HSPA5
Tchem
Novelty: 0.00043424
Score: 0.953
Data Source: STRINGDB
CEBPB
Tbio
Family: TF
Novelty: 0.00068108
Score: 0.925
Data Source: STRINGDB
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
Score: 0.918
Data Source: STRINGDB
BCL2L11
Tbio
Novelty: 0.00055914
Score: 0.917
Data Source: STRINGDB
NFYA
Tbio
Family: TF
Novelty: 0.00507094
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  915.06

PubMed score by year
PubTator Score  4034.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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