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Tchem
GRK3
Beta-adrenergic receptor kinase 2

Protein Summary
Description
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors. The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324198
  • ENSP00000317578
  • ENSG00000100077

Symbol
  • ADRBK2
  • BARK2
  • BARK2
  • ADRBK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.3   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.3   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
28
81.7
left atrial function
1
1
1
42.3
left ventricular structural measurement
1
1
1
38.2
mathematical ability
1
1
0
4.9
36.9
1
1
0
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
28
81.7
left atrial function
1
42.3
left ventricular structural measurement
1
38.2
mathematical ability
0
4.9
36.9
0
1
36.5
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor kinase 3
VGNC:12879
100614029
Macaque
G protein-coupled receptor kinase 3
714510
Mouse
MGI:87941
320129
C. elegans
175223
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor kinase 3
Macaque
G protein-coupled receptor kinase 3
Mouse
C. elegans
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35626-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (65)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
G alpha (s) signalling events
GPCR downstream signalling
Membrane Trafficking
Protein-Protein Interactions (450)
1 – 10 of 450
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.967
Data Source:  BioPlex,STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
Score:  0.972
Data Source:  STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
Score:  0.971
Data Source:  STRINGDB
ADRB2
Tclin
Family:  GPCR
Novelty:  0.00041821
Score:  0.967
Data Source:  Reactome,STRINGDB
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
Score:  0.941
Data Source:  STRINGDB
AVPR2
Tclin
Family:  GPCR
Novelty:  0.0009139
Score:  0.936
Data Source:  Reactome,STRINGDB
F2R
Tclin
Family:  GPCR
Novelty:  0.00080964
Score:  0.919
Data Source:  STRINGDB
GRK5
Tchem
Family:  Kinase
Novelty:  0.01108012
Score:  0.918
Data Source:  STRINGDB
TBXA2R
Tclin
Family:  GPCR
Novelty:  0.00571066
Score:  0.917
Data Source:  STRINGDB
GRK6
Tchem
Family:  Kinase
Novelty:  0.02740874
Score:  0.917
Data Source:  STRINGDB
Publication Statistics
PubMed Score  49.30

PubMed score by year
PubTator Score  96.06

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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