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Tbio
BSG
Basigin

Protein Summary
Description
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:21778275). Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333511
  • ENSP00000333769
  • ENSG00000172270
  • ENST00000346916
  • ENSP00000344707
  • ENST00000353555
  • ENSP00000343809
  • ENST00000545507
  • ENSP00000473664

Symbol
  • OK
  • 5F7
  • TCSF
  • CD147
  • EMPRIN
  • EMMPRIN
  • SLC7A11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
disease perturbation
0.93
interacting protein
0.89
protein domain
0.85
transcription factor binding site profile
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1522.35   (req: < 5)
Gene RIFs: 455   (req: <= 3)
Antibodies: 1797   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1522.35   (req: >= 5)
Gene RIFs: 455   (req: > 3)
Antibodies: 1797   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (227)
TARBP1
Tbio
Family:  Enzyme
Novelty:  0.04886897
p_int:  0.99999401
p_ni:  0.00000599
Data Source:  BioPlex
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
p_int:  0.999988042
p_ni:  0.000011958
Data Source:  BioPlex
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
p_int:  0.999862002
p_ni:  0.000137998
Score:  0.159
Data Source:  BioPlex,STRINGDB
UTP20
Tbio
Novelty:  0.09170451
p_int:  0.999823662
p_ni:  0.000176338
Data Source:  BioPlex
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
p_int:  0.999703694
p_ni:  0.000296306
Score:  0.176
Data Source:  BioPlex,STRINGDB
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
p_int:  0.999601328
p_ni:  0.000398672
Data Source:  BioPlex
TBRG4
Tbio
Novelty:  0.03556613
p_int:  0.99948129
p_ni:  0.00051871
Score:  0.151
Data Source:  BioPlex,STRINGDB
TTI2
Tdark
Novelty:  0.18394695
p_int:  0.999450854
p_ni:  0.000549146
Data Source:  BioPlex
SYMPK
Tbio
Novelty:  0.01773552
p_int:  0.999160089
p_ni:  0.000839911
Data Source:  BioPlex
ABCD1
Tbio
Family:  Transporter
Novelty:  0.0067013
p_int:  0.99911507
p_ni:  0.000847755
p_wrong:  0.000037175
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Basigin interactions (R-HSA-210991)

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Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
Reactome
Degradation of the extracellular matrix
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Basigin interactions
Cell surface interactions at the vascular wall
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
Degradation of the extracellular matrix
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal resistance factor
1
1
1
44.7
mean reticulocyte volume
1
1
1
39.7
disease progression measurement
1
1
0
1.9
38.6
prostate cancer
1
1
0
1.9
38.6
sex hormone-binding globulin measurement
3
2
3
31.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal resistance factor
1
44.7
mean reticulocyte volume
1
39.7
disease progression measurement
0
1.9
38.6
prostate cancer
0
1.9
38.6
sex hormone-binding globulin measurement
3
31.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basigin (Ok blood group)
VGNC:10910
749868
Macaque
basigin (Ok blood group)
721068
Mouse
MGI:88208
12215
Rat
RGD:2220
25246
Dog
basigin
VGNC:54577
476758
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basigin (Ok blood group)
Macaque
basigin (Ok blood group)
Mouse
Rat
Dog
basigin
Publication Statistics
PubMed Score 1522.35
PubMed score by year
PubTator Score 667.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title