Tbio BSG Basigin

Protein Summary

Description

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (PubMed:21778275). Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes. The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35613
• A6NJW1
• D3YLG5
• Q7Z796
• Q8IZL7

Gene Name

• BSG

Ensembl ID

• ENST00000333511
• ENSP00000333769
• ENSG00000172270
• ENST00000346916
• ENSP00000344707
• ENST00000353555
• ENSP00000343809
• ENST00000545507
• ENSP00000473664

Symbol

• OK
• 5F7
• TCSF
• CD147
• EMPRIN
• EMMPRIN
• SLC7A11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
disease perturbation	0.93
interacting protein	0.89
protein domain	0.85
transcription factor binding site profile	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1522.35   (req: < 5)

Gene RIFs: 556   (req: <= 3)

Antibodies: 1797   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1522.35   (req: >= 5)

Gene RIFs: 556   (req: > 3)

Antibodies: 1797   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0