Tbio ADD2 Beta-adducin

Protein Summary

Description

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P35612
• A8K4P2
• B4DM17
• D6W5G7
• D6W5G8
• Q13482
• Q16412
• Q59G82
• Q5U5P4
• Q6P0P2
• Q6PGQ4
• Q7Z688
• Q7Z689
• Q7Z690
• Q7Z691

Gene Name

• ADD2

Ensembl ID

• ENST00000264436
• ENSP00000264436
• ENSG00000075340
• ENST00000355733
• ENSP00000347972
• ENST00000403045
• ENSP00000384303
• ENST00000407644
• ENSP00000384677
• ENST00000413157
• ENSP00000388072
• ENST00000430656
• ENSP00000398112

Symbol

• ADDB
• ADDB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.94
virus perturbation	0.83
hub protein	0.79
tissue sample	0.7
microRNA	0.68

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Beta-adducin

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Beta-adducin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.58   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.58   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (56)

Explore Interacting Targets

1 – 10 of 56

• See Interactions on String-DB

CTAG2

Tbio

Novelty:  0.02983879

p_int:  0.99999978

p_ni:  2.2e-7

Data Source:  BioPlex

NUDT12

Tbio

Family:  Enzyme

Novelty:  0.18740719

p_int:  0.999999413

p_ni:  5.84e-7

p_wrong:  4e-9

Score:  0.174

Data Source:  BioPlex,STRINGDB

ANKRD29

Tdark

Novelty:  1.29202649

p_int:  0.999998301

p_ni:  8.64e-7

p_wrong:  8.36e-7

Score:  0.827

Data Source:  BioPlex,STRINGDB

DPPA4

Tbio

Novelty:  0.05764302

p_int:  0.999998159

p_ni:  0.000001839

p_wrong:  2e-9

Score:  0.527

Data Source:  BioPlex,STRINGDB

ADD1

Tbio

Family:  Enzyme

Novelty:  0.0040587

p_int:  0.999995979

p_ni:  0.000004021

Score:  0.987

Data Source:  BioPlex,Reactome,STRINGDB

ADD3

Tbio

Family:  Enzyme

Novelty:  0.02164464

p_int:  0.999943751

p_ni:  0.000056249

Score:  0.659

Data Source:  BioPlex,STRINGDB

ROCK1

Tclin

Family:  Kinase

Novelty:  0.00156045

p_int:  0.999785338

p_ni:  0.000211667

p_wrong:  0.000002995

Score:  0.852

Data Source:  BioPlex,STRINGDB

DEF6

Tbio

Novelty:  0.0378487

p_int:  0.991399005

p_ni:  0.008600923

p_wrong:  7.1e-8

Data Source:  BioPlex

ROCK2

Tclin

Family:  Kinase

Novelty:  0.00242311

p_int:  0.989967403

p_ni:  0.009995901

p_wrong:  0.000036696

Score:  0.774

Data Source:  BioPlex,STRINGDB

SERPINB13

Tbio

Novelty:  0.01753451

p_int:  0.988063175

p_ni:  0.011936172

p_wrong:  6.53e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

Reactome (2)

Miscellaneous transport and binding events (R-HSA-5223345)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Miscellaneous transport and binding events	24 targets	R-HSA-5223345
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Miscellaneous transport and binding events	24 targets	R-HSA-5223345
Transport of small molecules	725 targets	R-HSA-382551

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (8)

Components (6)

Processes (10)

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1 – 8 of 8

GO Term	Evidence	Assigned by
actin filament binding	Inferred from Direct Assay (IDA)	BHF-UCL
spectrin binding	Inferred from Direct Assay (IDA)	BHF-UCL
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
protein homodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
protein kinase binding	Inferred from Physical Interaction (IPI)	CAFA
actin binding	Inferred from Mutant Phenotype (IMP)	CAFA
structural molecule activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2	2	2		69.1
hair shape measurement	EFO_0007824	1	1	1		9
influenza A (H1N1)	EFO_1001488	1	1	0	19.4	7.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	2		69.1
hair shape measurement	EFO_0007824	1		9
influenza A (H1N1)	EFO_1001488	0	19.4	7.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Actin-binding
Alternative splicing
Calmodulin-binding
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Membrane
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
hair shape measurement
heel bone mineral density
influenza A (H1N1)

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
nervous system phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	adducin 2	VGNC:8	459305
Macaque	adducin 2		702939
Mouse	adducin 2 (beta)	MGI:87919	11519
Rat	adducin 2	RGD:2042	24171
Dog	adducin 2	VGNC:37629	610670

Species	Name	OMA	EggNOG	Inparanoid
Chimp	adducin 2
Macaque	adducin 2
Mouse	adducin 2 (beta)
Rat	adducin 2
Dog	adducin 2

Publication Statistics

PubMed Score 97.58

PubMed score by year

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PubTator Score 42.25

PubTator score by year

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Related Publications

Text Mined References (56)

GeneRif Annotations (21)

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PMID	Year	Title