Protein Summary
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associa ...more
- ENST00000264436
- ENSP00000264436
- ENSG00000075340
- ENST00000355733
- ENSP00000347972
- ENST00000403045
- ENSP00000384303
- ENST00000407644
- ENSP00000384677
- ENST00000413157
- ENSP00000388072
- ENST00000430656
- ENSP00000398112
- ADDB
- ADDB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase | 0.94 | ||
virus perturbation | 0.83 | ||
hub protein | 0.79 | ||
tissue sample | 0.7 | ||
microRNA | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 97.58 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 202 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 97.58 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 202 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (56)
NUDT12
Family: Enzyme
Novelty: 0.18740719
p_int: 0.999999413
p_ni: 5.84e-7
p_wrong: 4e-9
Score: 0.174
Data Source: BioPlex,STRINGDB
ANKRD29
Novelty: 1.29202649
p_int: 0.999998301
p_ni: 8.64e-7
p_wrong: 8.36e-7
Score: 0.827
Data Source: BioPlex,STRINGDB
DPPA4
Novelty: 0.05764302
p_int: 0.999998159
p_ni: 0.000001839
p_wrong: 2e-9
Score: 0.527
Data Source: BioPlex,STRINGDB
ADD1
Family: Enzyme
Novelty: 0.0040587
p_int: 0.999995979
p_ni: 0.000004021
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
ADD3
Family: Enzyme
Novelty: 0.02164464
p_int: 0.999943751
p_ni: 0.000056249
Score: 0.659
Data Source: BioPlex,STRINGDB
ROCK1
Family: Kinase
Novelty: 0.00156045
p_int: 0.999785338
p_ni: 0.000211667
p_wrong: 0.000002995
Score: 0.852
Data Source: BioPlex,STRINGDB
DEF6
Novelty: 0.0378487
p_int: 0.991399005
p_ni: 0.008600923
p_wrong: 7.1e-8
Data Source: BioPlex
ROCK2
Family: Kinase
Novelty: 0.00242311
p_int: 0.989967403
p_ni: 0.009995901
p_wrong: 0.000036696
Score: 0.774
Data Source: BioPlex,STRINGDB
SERPINB13
Novelty: 0.01753451
p_int: 0.988063175
p_ni: 0.011936172
p_wrong: 6.53e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Miscellaneous transport and binding events | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Miscellaneous transport and binding events | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (8)
Components (6)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 2 | 2 | 69.1 | |||||
hair shape measurement | 1 | 1 | 1 | 9 | |||||
influenza A (H1N1) | 1 | 1 | 0 | 19.4 | 7.6 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 69.1 | |||||
hair shape measurement | 1 | 9 | |||||
influenza A (H1N1) | 0 | 19.4 | 7.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | adducin 2 | VGNC:8 | 459305 | |||||
Macaque | adducin 2 | 702939 | ||||||
Mouse | MGI:87919 | 11519 | ||||||
Rat | RGD:2042 | 24171 | ||||||
Dog | adducin 2 | VGNC:37629 | 610670 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | adducin 2 | |||||
Macaque | adducin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | adducin 2 | |||||
Publication Statistics
PubMed Score 97.58
PubMed score by year
PubTator Score 42.25
PubTator score by year
Related Publications
Text Mined References (56)
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Year | Title |
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