Protein Summary
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
- ENST00000264758
- ENSP00000264758
- ENSG00000087274
- ENST00000355842
- ENSP00000348100
- ENST00000398123
- ENSP00000381191
- ENST00000398125
- ENSP00000381193
- ENST00000398129
- ENSP00000381197
- ADDA
- ADDA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
ligand (protein) perturbation | 1 | ||
kinase perturbation | 0.99 | ||
kinase | 0.97 | ||
biological process | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 253.71 (req: < 5)
Gene RIFs: 113 (req: <= 3)
Antibodies: 720 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 253.71 (req: >= 5)
Gene RIFs: 113 (req: > 3)
Antibodies: 720 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (85)
ADD2
Family: Enzyme
Novelty: 0.01097975
p_int: 0.999995979
p_ni: 0.000004021
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
ATP6V1D
Family: Enzyme
Novelty: 0.02298626
p_int: 0.999902574
p_ni: 0.000097426
Data Source: BioPlex
ANKRD29
Novelty: 1.29202649
p_int: 0.999765248
p_ni: 0.000234752
Score: 0.869
Data Source: BioPlex,STRINGDB
GBP2
Novelty: 0.01803054
p_int: 0.998231431
p_ni: 0.001768569
Score: 0.199
Data Source: BioPlex,STRINGDB
DPPA4
Novelty: 0.05764302
p_int: 0.994730279
p_ni: 0.005269721
Score: 0.692
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
Reactome (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Caspase-mediated cleavage of cytoskeletal proteins | ||||
Reactome | IRE1alpha activates chaperones | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Caspase-mediated cleavage of cytoskeletal proteins | ||||
IRE1alpha activates chaperones | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (10)
Components (12)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 1 | 1 | 68.3 | |||||
household income | 2 | 5 | 5 | 63.4 | |||||
cigarettes per day measurement | 3 | 3 | 3 | 60.2 | |||||
smoking initiation | 2 | 1 | 2 | 56.4 | |||||
1 | 1 | 1 | 49.5 | ||||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 68.3 | |||||
household income | 5 | 63.4 | |||||
cigarettes per day measurement | 3 | 60.2 | |||||
smoking initiation | 2 | 56.4 | |||||
1 | 49.5 | ||||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | adducin 1 | VGNC:6404 | 740376 | |||||
Macaque | adducin 1 | 700805 | ||||||
Mouse | MGI:87918 | 11518 | ||||||
Rat | RGD:2041 | 24170 | ||||||
Dog | adducin 1 | VGNC:37628 | 488796 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | adducin 1 | |||||
Macaque | adducin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | adducin 1 | |||||
Publication Statistics
PubMed Score 253.71
PubMed score by year
PubTator Score 270.58
PubTator score by year
Related Publications
Text Mined References (204)
GeneRif Annotations (113)
Items per page:
0 of 0
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