Tbio ADD1 Alpha-adducin

Protein Summary

Description

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P35611
• A2A3N8
• A2A3P0
• B4DI79
• D3DVR3
• D3DVR4
• D3DVR5
• Q13734
• Q14729
• Q16156
• Q86XM2
• Q9UJB6

Gene Name

• ADD1

Ensembl ID

• ENST00000264758
• ENSP00000264758
• ENSG00000087274
• ENST00000355842
• ENSP00000348100
• ENST00000398123
• ENSP00000381191
• ENST00000398125
• ENSP00000381193
• ENST00000398129
• ENSP00000381197

Symbol

• ADDA
• ADDA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
ligand (protein) perturbation	1
kinase perturbation	0.99
kinase	0.97
biological process	0.96

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.71   (req: < 5)

Gene RIFs: 113   (req: <= 3)

Antibodies: 720   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.71   (req: >= 5)

Gene RIFs: 113   (req: > 3)

Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Protein-Protein Interactions (85)

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1 – 10 of 85

• See Interactions on String-DB

ADD2

Tbio

Family:  Enzyme

Novelty:  0.01097975

p_int:  0.999995979

p_ni:  0.000004021

Score:  0.987

Data Source:  BioPlex,Reactome,STRINGDB

ATP6V1D

Tbio

Family:  Enzyme

Novelty:  0.02298626

p_int:  0.999902574

p_ni:  0.000097426

Data Source:  BioPlex

ANKRD29

Tdark

Novelty:  1.29202649

p_int:  0.999765248

p_ni:  0.000234752

Score:  0.869

Data Source:  BioPlex,STRINGDB

GBP2

Tbio

Novelty:  0.01803054

p_int:  0.998231431

p_ni:  0.001768569

Score:  0.199

Data Source:  BioPlex,STRINGDB

DPPA4

Tbio

Novelty:  0.05764302

p_int:  0.994730279

p_ni:  0.005269721

Score:  0.692

Data Source:  BioPlex,STRINGDB

CADPS

Tbio

Novelty:  0.01737775

p_int:  0.89815359

p_ni:  0.101846409

Data Source:  BioPlex

ADD3

Tbio

Family:  Enzyme

Novelty:  0.02164464

Score:  0.964

Data Source:  Reactome,STRINGDB

DMTN

Tbio

Novelty:  0.01330153

Score:  0.957

Data Source:  Reactome,STRINGDB

CASP3

Tchem

Family:  Enzyme

Novelty:  0.00003555

Score:  0.937

Data Source:  Reactome,STRINGDB

CAPZA2

Tbio

Novelty:  0.14014918

Score:  0.74

Data Source:  STRINGDB

Pathways (11)

Reactome (11)

Apoptosis (R-HSA-109581)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Reactome	Apoptotic execution phase	52 targets	R-HSA-75153
Reactome	Caspase-mediated cleavage of cytoskeletal proteins	12 targets	R-HSA-264870
Reactome	IRE1alpha activates chaperones	50 targets	R-HSA-381070

Name	Explore in Pharos	Explore in Source
Apoptosis	177 targets	R-HSA-109581
Apoptotic cleavage of cellular proteins	38 targets	R-HSA-111465
Apoptotic execution phase	52 targets	R-HSA-75153
Caspase-mediated cleavage of cytoskeletal proteins	12 targets	R-HSA-264870
IRE1alpha activates chaperones	50 targets	R-HSA-381070

Gene Ontology Terms (38)

Functions (10)

Components (12)

Processes (16)

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GO Term	Evidence	Assigned by
actin filament binding	Inferred from Direct Assay (IDA)	BHF-UCL
spectrin binding	Inferred from Direct Assay (IDA)	BHF-UCL
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
protein homodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
transcription factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural molecule activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
actin binding	Traceable Author Statement (TAS)	ProtInc
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

GWAS Traits (14)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1	1	1		68.3
household income	EFO_0009695	2	5	5		63.4
cigarettes per day measurement	EFO_0006525	3	3	3		60.2
smoking initiation	EFO_0005670	2	1	2		56.4
Hodgkins lymphoma	EFO_0000183	1	1	1		49.5

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1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1		68.3
household income	EFO_0009695	5		63.4
cigarettes per day measurement	EFO_0006525	3		60.2
smoking initiation	EFO_0005670	2		56.4
Hodgkins lymphoma	EFO_0000183	1		49.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Actin-binding
Alternative splicing
Calmodulin-binding
Cell membrane
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
aging
attention deficit hyperactivity disorder
biological sex
BMI-adjusted hip circumference
cigarettes per day measurement
cups of coffee per day measurement
Hodgkins lymphoma
household income
mean platelet volume
monocyte percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
growth/size/body region phenotype
hematopoietic system phenotype
mortality/aging
nervous system phenotype

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	adducin 1	VGNC:6404	740376
Macaque	adducin 1		700805
Mouse	adducin 1 (alpha)	MGI:87918	11518
Rat	adducin 1	RGD:2041	24170
Dog	adducin 1	VGNC:37628	488796

Species	Name	OMA	EggNOG	Inparanoid
Chimp	adducin 1
Macaque	adducin 1
Mouse	adducin 1 (alpha)
Rat	adducin 1
Dog	adducin 1

Publication Statistics

PubMed Score 253.71

PubMed score by year

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PubTator Score 270.58

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