ADD1
Alpha-adducin
Protein Summary
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
- ENST00000264758
- ENSP00000264758
- ENSG00000087274
- ENST00000355842
- ENSP00000348100
- ENST00000398123
- ENSP00000381191
- ENST00000398125
- ENSP00000381193
- ENST00000398129
- ENSP00000381197
- ADDA
- ADDA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
ligand (protein) perturbation | 1 | ||
kinase perturbation | 0.99 | ||
kinase | 0.97 | ||
biological process | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 333.04 (req: < 5)
Gene RIFs: 120 (req: <= 3)
Antibodies: 720 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 333.04 (req: >= 5)
Gene RIFs: 120 (req: > 3)
Antibodies: 720 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0