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Tbio
ADD1
Alpha-adducin

Protein Summary
Description
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264758
  • ENSP00000264758
  • ENSG00000087274
  • ENST00000355842
  • ENSP00000348100
  • ENST00000398123
  • ENSP00000381191
  • ENST00000398125
  • ENSP00000381193
  • ENST00000398129
  • ENSP00000381197

Symbol
  • ADDA
  • ADDA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
ligand (protein) perturbation
1
kinase perturbation
0.99
kinase
0.97
biological process
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.72   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 720   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.72   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
88.7
smoking initiation
2
1
2
83.8
smoking behaviour measurement
1
1
1
74.1
cups of coffee per day measurement
1
1
1
50
household income
2
2
2
42.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
88.7
smoking initiation
2
83.8
smoking behaviour measurement
1
74.1
cups of coffee per day measurement
1
50
household income
2
42.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adducin 1
VGNC:6404
740376
Macaque
adducin 1
700805
Mouse
MGI:87918
11518
Rat
RGD:2041
24170
Dog
adducin 1
VGNC:37628
488796
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adducin 1
Macaque
adducin 1
Mouse
Rat
Dog
adducin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35611-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Caspase-mediated cleavage of cytoskeletal proteins
Reactome
IRE1alpha activates chaperones
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Caspase-mediated cleavage of cytoskeletal proteins
IRE1alpha activates chaperones
Gene Ontology Terms (38)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (85)
1 – 10 of 85
ADD2
Tbio
Family: Enzyme
Novelty: 0.01097975
p_int: 0.999995979
p_ni: 0.000004021
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
ATP6V1D
Tbio
Family: Enzyme
Novelty: 0.02298626
p_int: 0.999902574
p_ni: 0.000097426
Data Source: BioPlex
ANKRD29
Tdark
Novelty: 1.29202649
p_int: 0.999765248
p_ni: 0.000234752
Score: 0.869
Data Source: BioPlex,STRINGDB
GBP2
Tbio
Novelty: 0.01803054
p_int: 0.998231431
p_ni: 0.001768569
Score: 0.199
Data Source: BioPlex,STRINGDB
DPPA4
Tbio
Novelty: 0.05764302
p_int: 0.994730279
p_ni: 0.005269721
Score: 0.692
Data Source: BioPlex,STRINGDB
CADPS
Tbio
Novelty: 0.01737775
p_int: 0.89815359
p_ni: 0.101846409
Data Source: BioPlex
ADD3
Tbio
Family: Enzyme
Novelty: 0.02164464
Score: 0.964
Data Source: Reactome,STRINGDB
DMTN
Tbio
Novelty: 0.01330153
Score: 0.957
Data Source: Reactome,STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00003555
Score: 0.937
Data Source: Reactome,STRINGDB
CAPZA2
Tbio
Novelty: 0.14014918
Score: 0.74
Data Source: STRINGDB
Publication Statistics
PubMed Score  251.72

PubMed score by year
PubTator Score  270.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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