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Tchem
SOAT1
Sterol O-acyltransferase 1

Protein Summary
Description
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367619
  • ENSP00000356591
  • ENSG00000057252
  • ENST00000539888
  • ENSP00000441356
  • ENST00000540564
  • ENSP00000445315

Symbol
  • ACACT
  • ACACT1
  • ACAT
  • ACAT1
  • SOAT
  • STAT
  • ACAT
  • SOAT
  • STAT
  • ACACT
  • ACAT1
  • ACAT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.96
transcription factor binding site profile
0.81
PubMedID
0.8
molecular function
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.01   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.01   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 131
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
3
4
99.3
chronotype measurement
1
1
1
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
99.3
chronotype measurement
1
82
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sterol O-acyltransferase 1
VGNC:10985
457553
Macaque
sterol O-acyltransferase 1
716989
Mouse
MGI:104665
20652
Rat
RGD:621641
81782
Dog
sterol O-acyltransferase 1
VGNC:46646
490325
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sterol O-acyltransferase 1
Macaque
sterol O-acyltransferase 1
Mouse
Rat
Dog
sterol O-acyltransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35610-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
LDL clearance (R-HSA-8964038)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
LDL clearance
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein clearance
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
LDL clearance
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein clearance
Transport of small molecules
Protein-Protein Interactions (99)
1 – 10 of 99
SEMA7A
Tbio
Novelty: 0.00741605
p_int: 0.999968505
p_ni: 0.000031495
Data Source: BioPlex
APOC2
Tbio
Novelty: 0.0015496
p_int: 0.999912112
p_ni: 0.000087888
Score: 0.245
Data Source: BioPlex,STRINGDB
CARNMT1
Tbio
Family: Enzyme
Novelty: 0.28121779
p_int: 0.999822129
p_ni: 0.000177871
Data Source: BioPlex
ECSCR
Tbio
Novelty: 0.11603718
p_int: 0.999803342
p_ni: 0.000196658
Data Source: BioPlex
ADAM33
Tchem
Family: Enzyme
Novelty: 0.00584097
p_int: 0.998942142
p_ni: 0.001057858
Data Source: BioPlex
LYPD6
Tbio
Novelty: 0.13867181
p_int: 0.998879981
p_ni: 0.001120019
Data Source: BioPlex
FAM187B
Tdark
Novelty: 0.59092623
p_int: 0.995721892
p_ni: 0.004278106
p_wrong: 2e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
RNF11
Tbio
Novelty: 0.04766714
p_int: 0.993315534
p_ni: 0.006684466
Score: 0.161
Data Source: BioPlex,STRINGDB
TSPAN5
Tbio
Novelty: 0.08879443
p_int: 0.982308336
p_ni: 0.017691663
p_wrong: 2e-9
Data Source: BioPlex
ASGR2
Tbio
Novelty: 0.14671716
p_int: 0.981094033
p_ni: 0.018905967
Data Source: BioPlex
Publication Statistics
PubMed Score  201.01

PubMed score by year
PubTator Score  251.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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