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Tbio
ACTN2
Alpha-actinin-2

Protein Summary
Description
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366578
  • ENSP00000355537
  • ENSG00000077522
  • ENST00000542672
  • ENSP00000443495

Symbol
  • CMH23
  • CMD1AA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
protein domain
0.92
biological process
0.84
interacting protein
0.81
hub protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.22   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.22   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
86.6
smoking initiation
1
1
1
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
86.6
smoking initiation
1
59.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actinin alpha 2
VGNC:31
469156
Macaque
actinin alpha 2
710012
Mouse
MGI:109192
11472
Rat
RGD:1308097
291245
Dog
actinin alpha 2
VGNC:37549
479191
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actinin alpha 2
Macaque
actinin alpha 2
Mouse
Rat
Dog
actinin alpha 2
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35609-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cell-Cell communication
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cell-Cell communication
Cytokine Signaling in Immune system
Gene Ontology Terms (53)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (290)
1 – 10 of 290
PDLIM1
Tbio
Novelty: 0.02703639
p_int: 0.963818161
p_ni: 0.036181839
Score: 0.806
Data Source: BioPlex,STRINGDB
ACTN4
Tbio
Novelty: 0.0040236
Score: 0.998
Data Source: STRINGDB
ACTN1
Tbio
Novelty: 0.00654004
Score: 0.998
Data Source: STRINGDB
MYH6
Tbio
Novelty: 0.00058671
Score: 0.997
Data Source: STRINGDB
MYH3
Tbio
Novelty: 0.00544794
Score: 0.996
Data Source: STRINGDB
TPM2
Tbio
Novelty: 0.00406572
Score: 0.995
Data Source: STRINGDB
TPM1
Tbio
Novelty: 0.00261206
Score: 0.995
Data Source: STRINGDB
TNNI1
Tbio
Novelty: 0.01639536
Score: 0.994
Data Source: STRINGDB
VCL
Tbio
Novelty: 0.00043107
Score: 0.992
Data Source: STRINGDB
MYH8
Tbio
Novelty: 0.01020559
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  138.22

PubMed score by year
PubTator Score  44.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer