You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MYH10
Myosin-10

Protein Summary
Description
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9. This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269243
  • ENSP00000269243
  • ENSG00000133026
  • ENST00000360416
  • ENSP00000353590
  • ENST00000379980
  • ENSP00000369315

Symbol
  • NMMHCB
  • NMMHC-IIB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
interacting protein
0.99
molecular function
0.99
transcription factor perturbation
0.94
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.92   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.92   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
36.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
36.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 10
VGNC:12476
455090
Mouse
MGI:1930780
77579
Rat
RGD:71000
79433
Dog
myosin heavy chain 10
VGNC:43535
479497
Horse
myosin heavy chain 10
VGNC:20477
100062708
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin heavy chain 10
Mouse
Rat
Dog
myosin heavy chain 10
Horse
myosin heavy chain 10
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35580-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHA-mediated growth cone collapse
Reactome
RHO GTPase Effectors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
RHO GTPase Effectors
Gene Ontology Terms (59)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (259)
1 – 10 of 259
MYL12B
Tbio
Novelty: 0.00999083
p_int: 0.999788869
p_ni: 0.000211132
Score: 0.983
Data Source: BioPlex,Reactome,STRINGDB
MYL3
Tbio
Novelty: 0.00493817
p_int: 0.997686011
p_ni: 0.002313989
Score: 0.963
Data Source: BioPlex,STRINGDB
MYL6
Tbio
Novelty: 0.00594485
p_int: 0.940227121
p_ni: 0.05977288
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
HSPA14
Tbio
Novelty: 0.01714625
p_int: 0.787164543
p_ni: 0.212835457
Data Source: BioPlex
MYH9
Tbio
Novelty: 0.0016488
Score: 0.984
Data Source: Reactome,STRINGDB
MYL9
Tbio
Novelty: 0.00309239
Score: 0.982
Data Source: Reactome,STRINGDB
MYLK
Tchem
Family: Kinase
Novelty: 0.00102277
Score: 0.963
Data Source: Reactome,STRINGDB
MYL1
Tbio
Novelty: 0.00360262
Score: 0.954
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.954
Data Source: STRINGDB
MYL6B
Tbio
Novelty: 0.01292785
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  141.92

PubMed score by year
PubTator Score  47.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: