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Tchem
G6PC
Glucose-6-phosphatase

Protein Summary
Description
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253801
  • ENSP00000253801
  • ENSG00000131482
  • ENST00000592383
  • ENSP00000465958

Symbol
  • G6PT
  • G6PT
  • GSD1
  • G6PC1
  • GSD1a
  • G6Pase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
disease perturbation
0.79
biological process
0.77
gene perturbation
0.67
cellular component
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1089.17   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1089.17   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
8.4
neutrophil percentage of leukocytes
1
1
1
2
lymphocyte percentage of leukocytes
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
8.4
neutrophil percentage of leukocytes
1
2
lymphocyte percentage of leukocytes
1
1.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucose-6-phosphatase catalytic subunit
VGNC:12142
454703
Macaque
glucose-6-phosphatase catalytic subunit
712053
Mouse
MGI:95607
14377
Rat
RGD:2644
25634
Dog
glucose-6-phosphatase catalytic subunit
VGNC:41040
403492
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucose-6-phosphatase catalytic subunit
Macaque
glucose-6-phosphatase catalytic subunit
Mouse
Rat
Dog
glucose-6-phosphatase catalytic subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35575-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (83)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Protein-Protein Interactions (163)
1 – 10 of 163
GCK
Tchem
Family: Kinase
Novelty: 0.00112778
Score: 0.973
Data Source: STRINGDB
HK1
Tchem
Family: Kinase
Novelty: 0.00195554
Score: 0.954
Data Source: STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.947
Data Source: STRINGDB
G6PD
Tchem
Family: Enzyme
Novelty: 0.00064455
Score: 0.946
Data Source: STRINGDB
PCK2
Tbio
Family: Kinase
Novelty: 0.0035563
Score: 0.939
Data Source: STRINGDB
H6PD
Tbio
Novelty: 0.00366637
Score: 0.928
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.923
Data Source: STRINGDB
PGM2
Tbio
Family: Enzyme
Novelty: 0.00922421
Score: 0.92
Data Source: STRINGDB
LCT
Tbio
Family: Enzyme
Novelty: 0.0019382
Score: 0.92
Data Source: STRINGDB
PGM1
Tbio
Family: Enzyme
Novelty: 0.00163947
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  1089.17

PubMed score by year
PubTator Score  1217.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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