Protein Summary
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hy ...more
- ENST00000253801
- ENSP00000253801
- ENSG00000131482
- ENST00000592383
- ENSP00000465958
- G6PT
- G6PT
- GSD1
- G6PC1
- GSD1a
- G6Pase
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.82 | ||
disease perturbation | 0.79 | ||
biological process | 0.77 | ||
gene perturbation | 0.67 | ||
cellular component | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1114.29 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 118 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1114.29 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 118 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (5)
Protein-Protein Interactions (163)
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (83)
Reactome (14)
KEGG (12)
PathwayCommons (3)
UniProt (1)
WikiPathways (53)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Reactome | FOXO-mediated transcription | ||||
Reactome | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
FOXO-mediated transcription | ||||
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Viral Interactions (0)
Gene Ontology Terms (20)
Functions (3)
Components (3)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 1 | 1 | 1 | 33.1 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 10 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 9.8 | |||||
body mass index | 1 | 1 | 1 | 4.4 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 1 | 33.1 | |||||
neutrophil percentage of leukocytes | 1 | 10 | |||||
lymphocyte percentage of leukocytes | 1 | 9.8 | |||||
body mass index | 1 | 4.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glucose-6-phosphatase catalytic subunit | VGNC:12142 | 454703 | |||||
Macaque | glucose-6-phosphatase catalytic subunit | 712053 | ||||||
Mouse | MGI:95607 | 14377 | ||||||
Rat | RGD:2644 | 25634 | ||||||
Dog | glucose-6-phosphatase catalytic subunit | VGNC:41040 | 403492 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glucose-6-phosphatase catalytic subunit | |||||
Macaque | glucose-6-phosphatase catalytic subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | glucose-6-phosphatase catalytic subunit | |||||
Publication Statistics
PubMed Score 1114.29
PubMed score by year
PubTator Score 1217.62
PubTator score by year
Related Publications
Text Mined References (76)
GeneRif Annotations (38)
Items per page:
0 of 0
PMID | Year | Title |
|---|