Protein Summary
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hy ...more
- ENST00000253801
- ENSP00000253801
- ENSG00000131482
- ENST00000592383
- ENSP00000465958
- G6PT
- G6PT
- GSD1
- G6PC1
- GSD1a
- G6Pase
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.82 | ||
disease perturbation | 0.79 | ||
biological process | 0.77 | ||
gene perturbation | 0.67 | ||
cellular component | 0.64 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1089.17 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 118 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1089.17 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 118 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (5)
1 – 5 of 5
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 1 | 1 | 1 | 8.4 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 2 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 1.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 1 | 8.4 | |||||
neutrophil percentage of leukocytes | 1 | 2 | |||||
lymphocyte percentage of leukocytes | 1 | 1.9 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glucose-6-phosphatase catalytic subunit | VGNC:12142 | 454703 | |||||
Macaque | glucose-6-phosphatase catalytic subunit | 712053 | ||||||
Mouse | MGI:95607 | 14377 | ||||||
Rat | RGD:2644 | 25634 | ||||||
Dog | glucose-6-phosphatase catalytic subunit | VGNC:41040 | 403492 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glucose-6-phosphatase catalytic subunit | |||||
Macaque | glucose-6-phosphatase catalytic subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | glucose-6-phosphatase catalytic subunit | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (83)
Reactome (14)
KEGG (12)
PathwayCommons (3)
UniProt (1)
WikiPathways (53)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 14
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Reactome | FOXO-mediated transcription | ||||
Reactome | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
FOXO-mediated transcription | ||||
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Gene Ontology Terms (20)
Functions (3)
Components (3)
Processes (14)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (163)
1 – 10 of 163
GCK
Family: Kinase
Novelty: 0.00112778
Score: 0.973
Data Source: STRINGDB
HK1
Family: Kinase
Novelty: 0.00195554
Score: 0.954
Data Source: STRINGDB
GPI
Family: Enzyme
Novelty: 0.00095404
Score: 0.947
Data Source: STRINGDB
G6PD
Family: Enzyme
Novelty: 0.00064455
Score: 0.946
Data Source: STRINGDB
PCK2
Family: Kinase
Novelty: 0.0035563
Score: 0.939
Data Source: STRINGDB
H6PD
Novelty: 0.00366637
Score: 0.928
Data Source: STRINGDB
INS
Novelty: 0.00000499
Score: 0.923
Data Source: STRINGDB
PGM2
Family: Enzyme
Novelty: 0.00922421
Score: 0.92
Data Source: STRINGDB
LCT
Family: Enzyme
Novelty: 0.0019382
Score: 0.92
Data Source: STRINGDB
PGM1
Family: Enzyme
Novelty: 0.00163947
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score 1089.17
PubMed score by year
PubTator Score 1217.62
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword