IRS1
Insulin receptor substrate 1
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These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated NTRK3 signals through PI3K | ||||
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated NTRK3 signals through PI3K | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of signal transduction | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 1 | 2 | 68.8 | |||||
reticulocyte measurement | 2 | 1 | 2 | 65.4 | |||||
reticulocyte count | 1 | 1 | 1 | 57.8 | |||||
sex hormone-binding globulin measurement | 1 | 1 | 1 | 47.7 | |||||
heel bone mineral density | 2 | 1 | 2 | 35 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 68.8 | |||||
reticulocyte measurement | 2 | 65.4 | |||||
reticulocyte count | 1 | 57.8 | |||||
sex hormone-binding globulin measurement | 1 | 47.7 | |||||
heel bone mineral density | 2 | 35 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | insulin receptor substrate 1 | VGNC:1981 | 459985 | |||||
Macaque | insulin receptor substrate 1 | 707870 | ||||||
Mouse | MGI:99454 | 16367 | ||||||
Rat | RGD:2922 | 25467 | ||||||
Dog | insulin receptor substrate 1 | VGNC:54317 | 486148 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | insulin receptor substrate 1 | |||||
Macaque | insulin receptor substrate 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | insulin receptor substrate 1 | |||||
PMID | Text |
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