IRS1
Insulin receptor substrate 1
Protein Summary
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2018.84 (req: < 5)
Gene RIFs: 304 (req: <= 3)
Antibodies: 2359 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2018.84 (req: >= 5)
Gene RIFs: 304 (req: > 3)
Antibodies: 2359 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (4)
1 – 4 of 4
GWAS Traits (6)
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GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 1 | 2 | 68.8 | |||||
reticulocyte measurement | 2 | 1 | 2 | 65.4 | |||||
reticulocyte count | 1 | 1 | 1 | 57.8 | |||||
sex hormone-binding globulin measurement | 1 | 1 | 1 | 47.7 | |||||
heel bone mineral density | 2 | 1 | 2 | 35 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 68.8 | |||||
reticulocyte measurement | 2 | 65.4 | |||||
reticulocyte count | 1 | 57.8 | |||||
sex hormone-binding globulin measurement | 1 | 47.7 | |||||
heel bone mineral density | 2 | 35 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | insulin receptor substrate 1 | VGNC:1981 | 459985 | |||||
Macaque | insulin receptor substrate 1 | 707870 | ||||||
Mouse | MGI:99454 | 16367 | ||||||
Rat | RGD:2922 | 25467 | ||||||
Dog | insulin receptor substrate 1 | VGNC:54317 | 486148 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | insulin receptor substrate 1 | |||||
Macaque | insulin receptor substrate 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | insulin receptor substrate 1 | |||||
Protein Structure (5 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (105)
Reactome (36)
KEGG (17)
PathwayCommons (28)
WikiPathways (24)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 36
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated NTRK3 signals through PI3K | ||||
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated NTRK3 signals through PI3K | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of signal transduction | ||||
Gene Ontology Terms (39)
Functions (11)
Components (7)
Processes (21)
Items per page:
10
1 – 10 of 11
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (363)
1 – 10 of 363
INSR
Family: Kinase
Novelty: 0.00230617
Score: 0.999
Data Source: Reactome,STRINGDB
PTPN11
Family: Enzyme
Novelty: 0.00073124
Score: 0.999
Data Source: STRINGDB
IGF1R
Family: Kinase
Novelty: 0.00034532
Score: 0.997
Data Source: Reactome,STRINGDB
INS
Novelty: 0.00000499
Score: 0.997
Data Source: Reactome,STRINGDB
RPS6KB1
Family: Kinase
Novelty: 0.00044681
Score: 0.996
Data Source: STRINGDB
PIK3R1
Family: Kinase
Novelty: 0.00179772
Score: 0.992
Data Source: Reactome,STRINGDB
IGF1
Novelty: 0.00003878
Score: 0.992
Data Source: Reactome,STRINGDB
SH2B2
Novelty: 0.20893668
Score: 0.992
Data Source: STRINGDB
GRB2
Novelty: 0.00091605
Score: 0.992
Data Source: Reactome,STRINGDB
MTOR
Family: Kinase
Novelty: 0.00012333
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score 2018.84
PubMed score by year
PubTator Score 1162.82
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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