IRS1
Insulin receptor substrate 1
Protein Summary
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
- ENST00000305123
- ENSP00000304895
- ENSG00000169047
- HIRS-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
hub protein | 1 | ||
kinase | 1 | ||
biological process | 0.99 | ||
gene perturbation | 0.98 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1977.03 (req: < 5)
Gene RIFs: 304 (req: <= 3)
Antibodies: 2359 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1977.03 (req: >= 5)
Gene RIFs: 304 (req: > 3)
Antibodies: 2359 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 1 | 1 | 1 | 67.7 | |||||
appendicular lean mass | 2 | 1 | 2 | 66.3 | |||||
heel bone mineral density | 2 | 1 | 2 | 55.8 | |||||
reticulocyte measurement | 2 | 1 | 2 | 35.2 | |||||
reticulocyte count | 1 | 1 | 1 | 29 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 1 | 67.7 | |||||
appendicular lean mass | 2 | 66.3 | |||||
heel bone mineral density | 2 | 55.8 | |||||
reticulocyte measurement | 2 | 35.2 | |||||
reticulocyte count | 1 | 29 | |||||
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (105)
Reactome (36)
KEGG (17)
PathwayCommons (28)
WikiPathways (24)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 36
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated NTRK3 signals through PI3K | ||||
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated NTRK3 signals through PI3K | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of signal transduction | ||||
Gene Ontology Terms (39)
Functions (11)
Components (7)
Processes (21)
Items per page:
10
1 – 10 of 11
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (363)
1 – 10 of 363
INSR
Family: Kinase
Novelty: 0.00230617
Score: 0.999
Data Source: Reactome,STRINGDB
PTPN11
Family: Enzyme
Novelty: 0.00073124
Score: 0.999
Data Source: STRINGDB
IGF1R
Family: Kinase
Novelty: 0.00034532
Score: 0.997
Data Source: Reactome,STRINGDB
INS
Novelty: 0.00000499
Score: 0.997
Data Source: Reactome,STRINGDB
RPS6KB1
Family: Kinase
Novelty: 0.00044681
Score: 0.996
Data Source: STRINGDB
PIK3R1
Family: Kinase
Novelty: 0.00179772
Score: 0.992
Data Source: Reactome,STRINGDB
IGF1
Novelty: 0.00003878
Score: 0.992
Data Source: Reactome,STRINGDB
SH2B2
Novelty: 0.20893668
Score: 0.992
Data Source: STRINGDB
GRB2
Novelty: 0.00091605
Score: 0.992
Data Source: Reactome,STRINGDB
MTOR
Family: Kinase
Novelty: 0.00012333
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score 1977.03
PubMed score by year
PubTator Score 1162.82
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
GWAS Trait