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Tchem
IRS1
Insulin receptor substrate 1

Protein Summary
Description
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305123
  • ENSP00000304895
  • ENSG00000169047

Symbol
  • HIRS-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
hub protein
1
kinase
1
biological process
0.99
gene perturbation
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2018.84   (req: < 5)
Gene RIFs: 304   (req: <= 3)
Antibodies: 2359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2018.84   (req: >= 5)
Gene RIFs: 304   (req: > 3)
Antibodies: 2359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
1
2
68.8
reticulocyte measurement
2
1
2
65.4
reticulocyte count
1
1
1
57.8
sex hormone-binding globulin measurement
1
1
1
47.7
heel bone mineral density
2
1
2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
68.8
reticulocyte measurement
2
65.4
reticulocyte count
1
57.8
sex hormone-binding globulin measurement
1
47.7
heel bone mineral density
2
35
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
insulin receptor substrate 1
VGNC:1981
459985
Macaque
insulin receptor substrate 1
707870
Mouse
MGI:99454
16367
Rat
RGD:2922
25467
Dog
insulin receptor substrate 1
VGNC:54317
486148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
insulin receptor substrate 1
Macaque
insulin receptor substrate 1
Mouse
Rat
Dog
insulin receptor substrate 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35568-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (105)
Activated NTRK3 signals through PI3K (R-HSA-9603381)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK3 signals through PI3K
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activated NTRK3 signals through PI3K
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (363)
1 – 10 of 363
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
Score:  0.999
Data Source:  Reactome,STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.999
Data Source:  STRINGDB
IGF1R
Tclin
Family:  Kinase
Novelty:  0.00034532
Score:  0.997
Data Source:  Reactome,STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.997
Data Source:  Reactome,STRINGDB
RPS6KB1
Tchem
Family:  Kinase
Novelty:  0.00044681
Score:  0.996
Data Source:  STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.992
Data Source:  Reactome,STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.992
Data Source:  Reactome,STRINGDB
SH2B2
Tbio
Novelty:  0.20893668
Score:  0.992
Data Source:  STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.992
Data Source:  Reactome,STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
Score:  0.99
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2018.84

PubMed score by year
PubTator Score  1162.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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