IRS1
Insulin receptor substrate 1
Protein Summary
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2018.84 (req: < 5)
Gene RIFs: 304 (req: <= 3)
Antibodies: 2359 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2018.84 (req: >= 5)
Gene RIFs: 304 (req: > 3)
Antibodies: 2359 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (363)
Nearest Tclin Targets (23)
Upstream (21)
Downstream (2)
1 – 5 of 21
Pathways (105)
Reactome (36)
KEGG (17)
PathwayCommons (28)
WikiPathways (24)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated NTRK3 signals through PI3K | ||||
Reactome | Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated NTRK3 signals through PI3K | ||||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of signal transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (39)
Functions (11)
Components (7)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 1 | 2 | 68.8 | |||||
reticulocyte measurement | 2 | 1 | 2 | 65.4 | |||||
reticulocyte count | 1 | 1 | 1 | 57.8 | |||||
sex hormone-binding globulin measurement | 1 | 1 | 1 | 47.7 | |||||
heel bone mineral density | 2 | 1 | 2 | 35 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 68.8 | |||||
reticulocyte measurement | 2 | 65.4 | |||||
reticulocyte count | 1 | 57.8 | |||||
sex hormone-binding globulin measurement | 1 | 47.7 | |||||
heel bone mineral density | 2 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | insulin receptor substrate 1 | VGNC:1981 | 459985 | |||||
Macaque | insulin receptor substrate 1 | 707870 | ||||||
Mouse | MGI:99454 | 16367 | ||||||
Rat | RGD:2922 | 25467 | ||||||
Dog | insulin receptor substrate 1 | VGNC:54317 | 486148 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | insulin receptor substrate 1 | |||||
Macaque | insulin receptor substrate 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | insulin receptor substrate 1 | |||||
Publication Statistics
PubMed Score 2018.84
PubMed score by year
PubTator Score 1162.82
PubTator score by year
Related Publications
GeneRif Annotations (304)
Items per page:
0 of 0
PMID | Text |
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