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Tbio
PCK1
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Protein Classes
Protein Summary
Description
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319441
  • ENSP00000319814
  • ENSG00000124253

Symbol
  • PEPCK1
  • PCKDC
  • PEPCK1
  • PEPCKC
  • PEPCK-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
gene perturbation
0.91
small molecule perturbation
0.83
disease
0.63
chemical
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.63   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 552   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.63   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 552   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (65)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
91.3
hematocrit
2
2
2
90.2
triglyceride measurement
6
4
6
79.6
glomerular filtration rate
3
1
3
73.3
alkaline phosphatase measurement
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
91.3
hematocrit
2
90.2
triglyceride measurement
6
79.6
glomerular filtration rate
3
73.3
alkaline phosphatase measurement
1
61.4
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoenolpyruvate carboxykinase 1
VGNC:6228
458362
Macaque
phosphoenolpyruvate carboxykinase 1
696207
Mouse
MGI:97501
18534
Rat
RGD:3267
362282
Dog
phosphoenolpyruvate carboxykinase 1
VGNC:44307
403560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoenolpyruvate carboxykinase 1
Macaque
phosphoenolpyruvate carboxykinase 1
Mouse
Rat
Dog
phosphoenolpyruvate carboxykinase 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35558-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (166)
Abacavir metabolism (R-HSA-2161541)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abacavir metabolism
Reactome
Abacavir transport and metabolism
Reactome
Developmental Biology
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Name
Explore in Pharos
Explore in Source
Abacavir metabolism
Abacavir transport and metabolism
Developmental Biology
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Gene Ontology Terms (39)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (228)
1 – 10 of 228
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
p_int:  0.999999388
p_ni:  1.8e-8
p_wrong:  5.93e-7
Score:  0.856
Data Source:  BioPlex,STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
Score:  0.979
Data Source:  STRINGDB
PKLR
Tbio
Family:  Kinase
Novelty:  0.00268398
Score:  0.966
Data Source:  STRINGDB
PPARGC1A
Tbio
Novelty:  0.0003625
Score:  0.962
Data Source:  STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.955
Data Source:  STRINGDB
MDH1
Tchem
Family:  Enzyme
Novelty:  0.00203876
Score:  0.954
Data Source:  STRINGDB
ACLY
Tclin
Family:  Enzyme
Novelty:  0.00114812
Score:  0.951
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.95
Data Source:  STRINGDB
ENO1
Tchem
Family:  Enzyme
Novelty:  0.00109178
Score:  0.946
Data Source:  STRINGDB
FABP4
Tchem
Novelty:  0.00107707
Score:  0.944
Data Source:  STRINGDB
Publication Statistics
PubMed Score  307.63

PubMed score by year
PubTator Score  459.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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