Tchem GCK Glucokinase

Protein Summary

Description

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage. This gene encodes a member of the hexokinase family of proteins. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. The use of multiple promoters and alternative splicing of this gene result in distinct protein isoforms that exhibit tissue-specific expression in the pancreas and liver. In the pancreas, this enzyme plays a role in glucose-stimulated insulin secretion, while in the liver, this enzyme is important in glucose uptake and conversion to glycogen. Mutations in this gene that alter enzyme activity have been associated with multiple types of diabetes and hyperinsulinemic hypoglycemia. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P35557
• A4D2J2
• A4D2J3
• Q05810

Gene Name

• GCK

Ensembl ID

• ENST00000345378
• ENSP00000223366
• ENSG00000106633
• ENST00000395796
• ENSP00000379142
• ENST00000403799
• ENSP00000384247
• ENST00000616242
• ENSP00000482149

Symbol

• GK
• GLK
• HK4
• HHF3
• HKIV
• HXKP
• LGLK
• MODY2
• FGQTL3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.99
phenotype	0.81
disease	0.8
trait	0.75

Protein Classes

DTO Classes

Protein / Kinase / Non-protein Kinase / Carbohydrate Kinase / Hexokinase Family / Glucokinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 854.86   (req: < 5)

Gene RIFs: 258   (req: <= 3)

Antibodies: 480   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 854.86   (req: >= 5)

Gene RIFs: 258   (req: > 3)

Antibodies: 480   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 99

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0