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Tbio
FBN2
Fibrillin-2

Protein Classes
Protein Summary
Description
Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262464
  • ENSP00000262464
  • ENSG00000138829
  • ENST00000508053
  • ENSP00000424571

Symbol
  • CCA
  • DA9
  • EOMD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
PubMedID
0.97
gene perturbation
0.91
trait
0.86
microRNA
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.07   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.07   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
5
98.6
testosterone measurement
3
3
3
94.8
appendicular lean mass
1
2
2
89
bone density
1
1
1
71
gut microbiome measurement
1
1
1
51.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
98.6
testosterone measurement
3
94.8
appendicular lean mass
2
89
bone density
1
71
gut microbiome measurement
1
51.8
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95490
14119
Rat
RGD:620910
689008
Dog
fibrillin 2
VGNC:40755
481491
Horse
fibrillin 2
VGNC:17934
100073031
Chicken
fibrillin 2
CGNC:49083
374203
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
fibrillin 2
Horse
fibrillin 2
Chicken
fibrillin 2
Protein Structure (0 Structures, 9 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Protein-Protein Interactions (91)
1 – 10 of 91
ZFP41
Tdark
Family: TF
Novelty: 3.33093006
p_int: 0.998896991
p_ni: 0.001103009
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.979431583
p_ni: 0.020568417
Data Source: BioPlex
MFAP5
Tbio
Novelty: 0.01839035
p_int: 0.973466113
p_ni: 0.026533887
Score: 0.966
Data Source: BioPlex,Reactome,STRINGDB
KLKB1
Tclin
Family: Enzyme
Novelty: 0.00109438
p_int: 0.968836973
p_ni: 0.031163027
Data Source: BioPlex
FOXD4L6
Tdark
Family: TF
Novelty: 9.78461538
p_int: 0.962406747
p_ni: 0.037593253
Score: 0.189
Data Source: BioPlex,STRINGDB
HRG
Tbio
Novelty: 0.0027048
p_int: 0.955816106
p_ni: 0.044183894
Data Source: BioPlex
GREM2
Tbio
Novelty: 0.01839564
p_int: 0.904186212
p_ni: 0.095813788
Data Source: BioPlex
LYPD4
Tbio
Novelty: 0.00381728
p_int: 0.890850633
p_ni: 0.109149367
Data Source: BioPlex
ADAMTSL1
Tbio
Novelty: 0.08853044
p_int: 0.884442954
p_ni: 0.115557046
Score: 0.491
Data Source: BioPlex,STRINGDB
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.839449698
p_ni: 0.160550302
Data Source: BioPlex
Publication Statistics
PubMed Score  188.07

PubMed score by year
PubTator Score  222.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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