Protein Summary
Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles. Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein ...more
- ENST00000316623
- ENSP00000325527
- ENSG00000166147
- FBN
- FBN
- SGS
- WMS
- MASS
- MFLS
- MFS1
- OCTD
- SSKS
- WMS2
- ACMICD
- ECTOL1
- GPHYSD2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.99 | ||
transcription factor perturbation | 0.98 | ||
biological term | 0.97 | ||
trait | 0.93 | ||
phenotype | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1506.83 (req: < 5)
Gene RIFs: 272 (req: <= 3)
Antibodies: 462 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1506.83 (req: >= 5)
Gene RIFs: 272 (req: > 3)
Antibodies: 462 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (238)
ZNF408
Family: TF
Novelty: 0.10649477
p_int: 0.999998957
p_ni: 0.000001026
p_wrong: 1.7e-8
Score: 0.15
Data Source: BioPlex,STRINGDB
ZFP41
Family: TF
Novelty: 3.33093006
p_int: 0.999998636
p_ni: 0.000001148
p_wrong: 2.17e-7
Data Source: BioPlex
HRG
Novelty: 0.0027048
p_int: 0.999995448
p_ni: 0.000001682
p_wrong: 0.00000287
Data Source: BioPlex
ODAPH
Novelty: 0.20386223
p_int: 0.999617853
p_ni: 0.000063935
p_wrong: 0.000318212
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (152)
Reactome (7)
KEGG (1)
PathwayCommons (3)
WikiPathways (141)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Elastic fibre formation | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Integrin cell surface interactions | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Elastic fibre formation | ||||
Extracellular matrix organization | ||||
Integrin cell surface interactions | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (35)
Functions (8)
Components (7)
Processes (20)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred by Curator (IC) | UniProtKB | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 2 | 4 | 3 | 2.1 | 92.7 | ||||
2 | 2 | 0 | 1.6 | 68.4 | |||||
refractive error measurement | 2 | 2 | 1 | 5.8 | 63.3 | ||||
BMI-adjusted waist circumference | 2 | 2 | 2 | 58.3 | |||||
central corneal thickness | 2 | 2 | 0 | 2.1 | 50.5 | ||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 3 | 2.1 | 92.7 | ||||
0 | 1.6 | 68.4 | |||||
refractive error measurement | 1 | 5.8 | 63.3 | ||||
BMI-adjusted waist circumference | 2 | 58.3 | |||||
central corneal thickness | 0 | 2.1 | 50.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | fibrillin 1 | VGNC:3543 | 453411 | |||||
Macaque | fibrillin 1 | 714451 | ||||||
Mouse | MGI:95489 | 14118 | ||||||
Rat | RGD:620908 | 83727 | ||||||
Dog | fibrillin 1 | VGNC:40754 | 478293 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | fibrillin 1 | |||||
Macaque | fibrillin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | fibrillin 1 | |||||
Publication Statistics
PubMed Score 1506.83
PubMed score by year
PubTator Score 958.07
PubTator score by year
Related Publications
Text Mined References (369)
GeneRif Annotations (272)
Items per page:
0 of 0
PMID | Year | Title |
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