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Tbio
MSX2
Homeobox protein MSX-2

Protein Summary
Description
Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239243
  • ENSP00000239243
  • ENSG00000120149

Symbol
  • HOX8
  • FPP
  • MSH
  • PFM
  • CRS2
  • HOX8
  • PFM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.99
virus perturbation
0.94
molecular function
0.86
gene perturbation
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 414.03   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 379   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 414.03   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.961035915
p_ni:  0.038964085
Score:  0.206
Data Source:  BioPlex,STRINGDB
ZNF703
Tbio
Novelty:  0.03956045
p_int:  0.840385759
p_ni:  0.159581569
p_wrong:  0.000032673
Score:  0.278
Data Source:  BioPlex,STRINGDB
HBS1L
Tbio
Novelty:  0.00125579
p_int:  0.751533799
p_ni:  0.248466201
Score:  0.535
Data Source:  BioPlex,STRINGDB
DLX5
Tbio
Family:  TF
Novelty:  0.00418303
Score:  0.951
Data Source:  STRINGDB
NKX3-2
Tbio
Family:  TF
Novelty:  0.01804711
Score:  0.924
Data Source:  STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.92
Data Source:  STRINGDB
DLX6
Tbio
Family:  TF
Novelty:  0.01455012
Score:  0.919
Data Source:  STRINGDB
CBFB
Tchem
Family:  TF
Novelty:  0.04825679
Score:  0.918
Data Source:  STRINGDB
HIVEP3
Tbio
Family:  TF
Novelty:  0.02321588
Score:  0.913
Data Source:  STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of RUNX2 expression and activity
Reactome
Transcriptional regulation by RUNX2
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of RUNX2 expression and activity
Transcriptional regulation by RUNX2
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (42)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
60.4
brain measurement
1
1
0
7.3
48
cortical surface area measurement
1
1
0
6.6
36.4
chin morphology measurement
1
1
0
1.2
27
grip strength measurement
1
1
0
8.7
11.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
60.4
brain measurement
0
7.3
48
cortical surface area measurement
0
6.6
36.4
chin morphology measurement
0
1.2
27
grip strength measurement
0
8.7
11.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
msh homeobox 2
VGNC:50800
744194
Mouse
MGI:97169
17702
Rat
RGD:3116
25483
Dog
msh homeobox 2
VGNC:43455
403663
Horse
msh homeobox 2
VGNC:20397
100058880
Species
Name
OMA
EggNOG
Inparanoid
Chimp
msh homeobox 2
Mouse
Rat
Dog
msh homeobox 2
Horse
msh homeobox 2
Publication Statistics
PubMed Score 414.03
PubMed score by year
PubTator Score 466.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title