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Tbio
P35544
Ubiquitin-like protein FUBI

Protein Summary
Description
This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000527548
  • ENSP00000434440
  • ENSG00000149806
  • ENST00000529639
  • ENSP00000435370
  • ENST00000531743
  • ENSP00000431822

Symbol
  • S30
  • FAU1
  • Fub1
  • Fubi
  • asr1
  • RPS30
  • MNSFbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
disease perturbation
0.99
interacting protein
0.96
hub protein
0.92
kinase perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.94   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.94   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (560)
RPLP2
Tbio
Novelty:  0.00323155
Score:  0.999
Data Source:  STRINGDB
RPS3
Tbio
Novelty:  0.003106
Score:  0.999
Data Source:  STRINGDB
RPS21
Tbio
Novelty:  0.00578555
Score:  0.999
Data Source:  STRINGDB
RPS11
Tbio
Novelty:  0.0168881
Score:  0.999
Data Source:  STRINGDB
RPL4
Tbio
Novelty:  0.00475169
Score:  0.999
Data Source:  STRINGDB
RPL24
Tbio
Novelty:  0.02160548
Score:  0.999
Data Source:  STRINGDB
RPL27A
Tbio
Novelty:  0.03424762
Score:  0.999
Data Source:  STRINGDB
RPL29
Tbio
Novelty:  0.0126026
Score:  0.999
Data Source:  STRINGDB
RPS18
Tbio
Novelty:  0.00688684
Score:  0.999
Data Source:  STRINGDB
RPS10
Tbio
Novelty:  0.01016071
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (51)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
3
6
90.7
high density lipoprotein cholesterol measurement
1
1
2
48.5
mean corpuscular hemoglobin
1
1
2
33.1
mean corpuscular volume
1
1
2
21.5
1
1
0
1.9
13.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
90.7
high density lipoprotein cholesterol measurement
2
48.5
mean corpuscular hemoglobin
2
33.1
mean corpuscular volume
2
21.5
0
1.9
13.9
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FAU, ubiquitin like and ribosomal protein S30 fusion
VGNC:11769
466658
Macaque
FAU, ubiquitin like and ribosomal protein S30 fusion
716761
Mouse
MGI:102547
14109
Rat
RGD:2321710
100360647
Dog
FAU, ubiquitin like and ribosomal protein S30 fusion
VGNC:51871
483748
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FAU, ubiquitin like and ribosomal protein S30 fusion
Macaque
FAU, ubiquitin like and ribosomal protein S30 fusion
Mouse
Rat
Dog
FAU, ubiquitin like and ribosomal protein S30 fusion
Publication Statistics
PubMed Score 152.94
PubMed score by year
PubTator Score 159.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title