Tchem CBS Cystathionine beta-synthase

Protein Summary

Description

Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P35520
• B2R993
• D3DSK4
• Q99425
• Q9BWC5

Gene Name

• CBS

Ensembl ID

• ENST00000352178
• ENSP00000344460
• ENSG00000160200
• ENST00000359624
• ENSP00000352643
• ENST00000398158
• ENSP00000381225
• ENST00000398165
• ENSP00000381231

Symbol

• CBSL
• HIP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Lyase / Dehydratase / Cystathionine Beta-synthase

Protein / Isomerase / Epimerase/racemase / Cystathionine Beta-synthase

Protein / Hydrolase / Deaminase / Cystathionine Beta-synthase

DTO Classes

Protein / Enzyme / Isomerase / Epimerase/racemase / Cystathionine Beta-synthase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5555.27   (req: < 5)

Gene RIFs: 211   (req: <= 3)

Antibodies: 457   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5555.27   (req: >= 5)

Gene RIFs: 211   (req: > 3)

Antibodies: 457   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0