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Tdark
UGT1A5
UDP-glucuronosyltransferase 1-5

Protein Summary
Description
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373414
  • ENSP00000362513
  • ENSG00000240224

Symbol
  • GNT1
  • UGT1
  • UDPGT
  • UGT1E
  • UDPGT 1-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
trait
0.75
cellular component
0.6
tissue
0.58
pathway
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.24   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.24   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
CYP2B6
Tchem
Novelty:  0.00018351
Score:  0.908
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.871
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.85
Data Source:  STRINGDB
SLC35A2
Tbio
Family:  Transporter
Novelty:  0.00072521
Score:  0.847
Data Source:  STRINGDB
CYP1A2
Tchem
Novelty:  0.00034756
Score:  0.842
Data Source:  STRINGDB
CYP2E1
Tchem
Novelty:  0.00030504
Score:  0.818
Data Source:  STRINGDB
UGDH
Tbio
Family:  Enzyme
Novelty:  0.00284931
Score:  0.816
Data Source:  STRINGDB
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.805
Data Source:  STRINGDB
CYP2A13
Tchem
Novelty:  0.00697238
Score:  0.8
Data Source:  STRINGDB
CYP3A5
Tclin
Family:  Enzyme
Novelty:  0.00105607
Score:  0.782
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
1 – 5 of 9
CYP19A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
SRD5A2
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  1
Pathways (17)
Biological oxidations (R-HSA-211859)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glucuronidation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glucuronidation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-glucuronosyltransferase 1-1
107973969
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-glucuronosyltransferase 1-1
Publication Statistics
PubMed Score 19.24
PubMed score by year
PubTator Score 5.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title