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Tclin
SCN4A
Sodium channel protein type 4 subunit alpha

Protein Classes
Protein Summary
Description
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000435607
  • ENSP00000396320
  • ENSG00000007314

Symbol
  • HYPP
  • SkM1
  • CMS16
  • HYKPP
  • NAC1A
  • HOKPP2
  • Nav1.4
  • Na(V)1.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.78
molecular function
0.76
disease perturbation
0.68
hub protein
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.61   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.61   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 158
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
8
10
97.7
BMI-adjusted hip circumference
2
8
9
93.3
appendicular lean mass
2
2
4
91.1
hematocrit
2
2
2
88.5
IGF-1 measurement
1
1
1
87.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
10
97.7
BMI-adjusted hip circumference
9
93.3
appendicular lean mass
4
91.1
hematocrit
2
88.5
IGF-1 measurement
1
87.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 4
VGNC:12667
100612017
Macaque
sodium voltage-gated channel alpha subunit 4
718194
Mouse
MGI:98250
110880
Rat
RGD:3636
25722
Dog
sodium voltage-gated channel alpha subunit 4
VGNC:45920
610754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 4
Macaque
sodium voltage-gated channel alpha subunit 4
Mouse
Rat
Dog
sodium voltage-gated channel alpha subunit 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35499-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Protein-Protein Interactions (108)
1 – 10 of 108
SCN3A
Tclin
Family:  IC
Novelty:  0.00646122
Score:  0.974
Data Source:  STRINGDB
SCN2A
Tclin
Family:  IC
Novelty:  0.0007317
Score:  0.974
Data Source:  STRINGDB
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
Score:  0.968
Data Source:  STRINGDB
SCN4B
Tbio
Family:  IC
Novelty:  0.02505113
Score:  0.958
Data Source:  STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
Score:  0.956
Data Source:  STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
Score:  0.954
Data Source:  STRINGDB
ANK3
Tbio
Novelty:  0.00429246
Score:  0.937
Data Source:  STRINGDB
ANK2
Tbio
Novelty:  0.00528351
Score:  0.925
Data Source:  STRINGDB
SPTBN5
Tbio
Novelty:  0.18740061
Score:  0.918
Data Source:  STRINGDB
ANK1
Tbio
Novelty:  0.00225305
Score:  0.913
Data Source:  STRINGDB
Publication Statistics
PubMed Score  574.61

PubMed score by year
PubTator Score  349.04

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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