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Tclin
SCN1A
Sodium channel protein type 1 subunit alpha

Protein Summary
Description
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli. Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene encodes a sodium ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303395
  • ENSP00000303540
  • ENSG00000144285
  • ENST00000375405
  • ENSP00000364554
  • ENST00000409050
  • ENSP00000386312
  • ENST00000423058
  • ENSP00000407030
  • ENST00000635750
  • ENSP00000490799
  • ENST00000637988
  • ENSP00000490780

Symbol
  • NAC1
  • SCN1
  • FEB3
  • FHM3
  • NAC1
  • SCN1
  • SMEI
  • EIEE6
  • FEB3A
  • HBSCI
  • GEFSP2
  • Nav1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.96
protein domain
0.92
cell type or tissue
0.79
molecular function
0.76
cell line
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 994.4   (req: < 5)
Gene RIFs: 270   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 994.4   (req: >= 5)
Gene RIFs: 270   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 23
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (173)
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
Score:  0.989
Data Source:  STRINGDB
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
Score:  0.974
Data Source:  STRINGDB
SCN4B
Tbio
Family:  IC
Novelty:  0.02505113
Score:  0.966
Data Source:  STRINGDB
ANK3
Tbio
Novelty:  0.00429246
Score:  0.96
Data Source:  STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
Score:  0.96
Data Source:  STRINGDB
ANK2
Tbio
Novelty:  0.00528351
Score:  0.952
Data Source:  STRINGDB
SPTAN1
Tbio
Novelty:  0.00286901
Score:  0.949
Data Source:  STRINGDB
NFASC
Tbio
Novelty:  0.00545331
Score:  0.948
Data Source:  STRINGDB
NRCAM
Tbio
Novelty:  0.00443497
Score:  0.938
Data Source:  STRINGDB
SPTBN4
Tbio
Novelty:  0.02182293
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
4.2
70.4
Febrile seizure (within the age range of 3 months to 6 years)
2
1
0
1.3
66.8
MMR-related febrile seizures
1
1
0
1.5
53.7
mathematical ability
3
2
3
50.5
self reported educational attainment
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4.2
70.4
Febrile seizure (within the age range of 3 months to 6 years)
0
1.3
66.8
MMR-related febrile seizures
0
1.5
53.7
mathematical ability
3
50.5
self reported educational attainment
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 1
VGNC:14353
459703
Macaque
sodium voltage-gated channel alpha subunit 1
704086
Mouse
MGI:98246
20265
Rat
RGD:69364
81574
Dog
sodium voltage-gated channel alpha subunit 1
VGNC:45915
478775
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium voltage-gated channel alpha subunit 1
Macaque
sodium voltage-gated channel alpha subunit 1
Mouse
Rat
Dog
sodium voltage-gated channel alpha subunit 1
Publication Statistics
PubMed Score 994.40
PubMed score by year
PubTator Score 618.84
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title