Tbio IDUA Alpha-L-iduronidase

Protein Summary

Description

This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35475
• B3KWK6

Gene Name

• IDUA

Ensembl ID

• ENST00000247933
• ENSP00000247933
• ENSG00000127415

Symbol

• IDA
• MPS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81
cellular component	0.77
transcription factor binding site profile	0.72
phenotype	0.69
PubMedID	0.65

Protein Classes

PANTHER Classes

Protein / Hydrolase / Glycosidase / Alpha-l-iduronidase

DTO Classes

Protein / Enzyme / Hydrolase / Glycosidase / Alpha-l-iduronidase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 454.05   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 454.05   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0