Tbio IDUA Alpha-L-iduronidase

Protein Classes

PANTHER Classes

Protein / Hydrolase / Glycosidase / Alpha-l-iduronidase

DTO Classes

Protein / Enzyme / Hydrolase / Glycosidase / Alpha-l-iduronidase

Protein Summary

Description

This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35475
• B3KWK6

Gene Name

• IDUA

Ensembl ID

• ENST00000247933
• ENSP00000247933
• ENSG00000127415

Symbol

• IDA
• MPS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81
cellular component	0.77
transcription factor binding site profile	0.72
phenotype	0.69
PubMedID	0.65

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.43   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.43   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (10)

1 – 5 of 10

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (16)

Reactome (12)

KEGG (3)

PathwayCommons (1)

CS/DS degradation (R-HSA-2024101)

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Items per page:

5

1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	CS/DS degradation	14 targets	R-HSA-2024101
Reactome	Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of carbohydrate metabolism	35 targets	R-HSA-5663084
Reactome	Diseases of metabolism	103 targets	R-HSA-5668914

Name	Explore in Pharos	Explore in Source
CS/DS degradation	14 targets	R-HSA-2024101
Chondroitin sulfate/dermatan sulfate metabolism	50 targets	R-HSA-1793185
Disease	1105 targets	R-HSA-1643685
Diseases of carbohydrate metabolism	35 targets	R-HSA-5663084
Diseases of metabolism	103 targets	R-HSA-5668914

Gene Ontology Terms (10)

Functions (2)

Components (3)

Processes (5)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
L-iduronidase activity	Inferred from Direct Assay (IDA)	UniProtKB
signaling receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (52)

Explore Interacting Targets

1 – 10 of 52

• See Interactions on String-DB

SCGB2A2

Tbio

Novelty: 0.01762536

p_int: 0.998595139

p_ni: 0.000001655

p_wrong: 0.001403207

Score: 0.188

Data Source: BioPlex,STRINGDB

PSCA

Tbio

Novelty: 0.00370639

p_int: 0.990684104

p_ni: 0.002151234

p_wrong: 0.007164662

Data Source: BioPlex

IDS

Tbio

Family: Enzyme

Novelty: 0.0090788

Score: 0.97

Data Source: STRINGDB

SGSH

Tbio

Family: Enzyme

Novelty: 0.00630911

Score: 0.968

Data Source: STRINGDB

ARSB

Tbio

Family: Enzyme

Novelty: 0.00299621

Score: 0.966

Data Source: STRINGDB

HEXA

Tchem

Family: Enzyme

Novelty: 0.00302415

Score: 0.932

Data Source: STRINGDB

HYAL1

Tbio

Family: Enzyme

Novelty: 0.01040168

Score: 0.923

Data Source: STRINGDB

SPAM1

Tbio

Family: Enzyme

Novelty: 0.00505307

Score: 0.92

Data Source: STRINGDB

HYAL4

Tbio

Family: Enzyme

Novelty: 0.15189873

Score: 0.912

Data Source: STRINGDB

HYAL3

Tbio

Family: Enzyme

Novelty: 0.19292605

Score: 0.902

Data Source: STRINGDB

Publication Statistics

PubMed Score  314.43

PubMed score by year

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PubTator Score  429.66

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MRPLRPRAALLALLASLLAAPPVAPAEAPHLVHVDAARALWPLRRFWRSTGFCPPLPHSQADQYVLSWDQ

1-70

QLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGRGLSYNFTHLDGYLDLLRENQLLPGFELMGSASGHF

70-140

TDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHHDFDNVSMTMQGFLNYYDACSEGLR

140-210

AASPALRLGGPGDSFHTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVA

210-280

QQIRQLFPKFADTPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALLSNDN

280-350

AFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGV

350-420

LASAHRPQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRL

420-490

GRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALPLT

490-560

QGQLVLVWSDEHVGSKCLWTYEIQFSQDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPG

560-630

PFSDPVPYLEVPVPRGPPSPGNP

630-653

MRPLRPRAALLALLASLLAAPPVAPAEAPHLVHVDAARALWPLRRFWRSTGFCPPLPHSQADQYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGRGLSYNFTHLDGYLDLLRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETWNEPDHHDFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRHCHDGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVAQQIRQLFPKFADTPIYNDEADPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALLSNDNAFLSYHPHPFAQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGVLASAHRPQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGLCSPDGEWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHVCARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQDGKAYTPVSRKPSTFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGPPSPGNP

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Glycosidase
Hydrolase
Lysosome
Mucopolysaccharidosis