Protein Classes
Protein Summary
This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]
- ENST00000247933
- ENSP00000247933
- ENSG00000127415
- IDA
- MPS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.81 | ||
cellular component | 0.77 | ||
transcription factor binding site profile | 0.72 | ||
phenotype | 0.69 | ||
PubMedID | 0.65 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 383.88 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 182 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 383.88 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 182 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 4 | 8 | 98 | |||||
bone density | 3 | 3 | 3 | 96.6 | |||||
cortical surface area measurement | 1 | 2 | 0 | 9.6 | 92.9 | ||||
appendicular lean mass | 1 | 1 | 1 | 69.4 | |||||
hip bone mineral density | 1 | 1 | 1 | 54.1 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 8 | 98 | |||||
bone density | 3 | 96.6 | |||||
cortical surface area measurement | 0 | 9.6 | 92.9 | ||||
appendicular lean mass | 1 | 69.4 | |||||
hip bone mineral density | 1 | 54.1 | |||||
Orthologs (11)
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Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | iduronidase, alpha-L- | 461056 | ||||||
Mouse | MGI:96418 | 15932 | ||||||
Rat | RGD:1310943 | 360904 | ||||||
Dog | iduronidase, alpha-L- | VGNC:41867 | 100505382 | |||||
Horse | iduronidase, alpha-L- | VGNC:18940 | 100146682 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | iduronidase, alpha-L- | |||||
Mouse | ||||||
Rat | ||||||
Dog | iduronidase, alpha-L- | |||||
Horse | iduronidase, alpha-L- | |||||
Protein Structure (10 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 10
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (16)
Reactome (12)
KEGG (3)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | CS/DS degradation | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
CS/DS degradation | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
Gene Ontology Terms (10)
Functions (2)
Components (3)
Processes (5)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (52)
1 – 10 of 52
SCGB2A2
Novelty: 0.01594053
p_int: 0.998595139
p_ni: 0.000001655
p_wrong: 0.001403207
Score: 0.188
Data Source: BioPlex,STRINGDB
PSCA
Novelty: 0.00323778
p_int: 0.990684104
p_ni: 0.002151234
p_wrong: 0.007164662
Data Source: BioPlex
IDS
Family: Enzyme
Novelty: 0.00733996
Score: 0.97
Data Source: STRINGDB
SGSH
Family: Enzyme
Novelty: 0.00670111
Score: 0.968
Data Source: STRINGDB
ARSB
Family: Enzyme
Novelty: 0.01044355
Score: 0.966
Data Source: STRINGDB
HEXA
Family: Enzyme
Novelty: 0.01134783
Score: 0.932
Data Source: STRINGDB
HYAL1
Family: Enzyme
Novelty: 0.00756819
Score: 0.923
Data Source: STRINGDB
SPAM1
Family: Enzyme
Novelty: 0.0041597
Score: 0.92
Data Source: STRINGDB
HYAL4
Family: Enzyme
Novelty: 0.10127674
Score: 0.912
Data Source: STRINGDB
HYAL3
Family: Enzyme
Novelty: 0.14284007
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score 383.88
PubMed score by year
PubTator Score 429.66
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait