Protein Summary
This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]
- ENST00000247933
- ENSP00000247933
- ENSG00000127415
- IDA
- MPS1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.81 | ||
cellular component | 0.77 | ||
transcription factor binding site profile | 0.72 | ||
phenotype | 0.69 | ||
PubMedID | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 389.11 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 182 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 389.11 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 182 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (52)
SCGB2A2
Novelty: 0.01594053
p_int: 0.998595139
p_ni: 0.000001655
p_wrong: 0.001403207
Score: 0.188
Data Source: BioPlex,STRINGDB
PSCA
Novelty: 0.00323778
p_int: 0.990684104
p_ni: 0.002151234
p_wrong: 0.007164662
Data Source: BioPlex
Nearest Tclin Targets
Pathways (16)
Reactome (12)
KEGG (3)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | CS/DS degradation | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
CS/DS degradation | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (2)
Components (3)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 13 | 21 | 99.7 | |||||
8 | 5 | 2 | 1.2 | 97.5 | |||||
waist-hip ratio | 3 | 9 | 9 | 91.1 | |||||
BMI-adjusted waist-hip ratio | 3 | 8 | 9 | 90.6 | |||||
bone density | 4 | 5 | 5 | 90.5 | |||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 21 | 99.7 | |||||
2 | 1.2 | 97.5 | |||||
waist-hip ratio | 9 | 91.1 | |||||
BMI-adjusted waist-hip ratio | 9 | 90.6 | |||||
bone density | 5 | 90.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | iduronidase, alpha-L- | 461056 | ||||||
Mouse | MGI:96418 | 15932 | ||||||
Rat | RGD:1310943 | 360904 | ||||||
Dog | iduronidase, alpha-L- | VGNC:41867 | 100505382 | |||||
Horse | iduronidase, alpha-L- | VGNC:18940 | 100146682 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | iduronidase, alpha-L- | |||||
Mouse | ||||||
Rat | ||||||
Dog | iduronidase, alpha-L- | |||||
Horse | iduronidase, alpha-L- | |||||
Publication Statistics
PubMed Score 389.11
PubMed score by year
PubTator Score 429.66
PubTator score by year
Related Publications
Text Mined References (71)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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