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Tclin
DRD3
D(3) dopamine receptor

Protein Summary
Description
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation. This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383673
  • ENSP00000373169
  • ENSG00000151577
  • ENST00000460779
  • ENSP00000419402
  • ENST00000467632
  • ENSP00000420662

Symbol
  • D3DR
  • ETM1
  • FET1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
ligand (chemical)
0.99
drug
0.98
chemical
0.87
molecular function
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.73   (req: < 5)
Gene RIFs: 236   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.73   (req: >= 5)
Gene RIFs: 236   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2478
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 58
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
55.6
feeling emotionally hurt measurement
1
1
0
5.5
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
55.6
feeling emotionally hurt measurement
0
5.5
15.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dopamine receptor D3
VGNC:1797
470885
Macaque
dopamine receptor D3
100425047
Mouse
MGI:94925
13490
Rat
RGD:2521
29238
Dog
dopamine receptor D3
VGNC:40095
487984
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dopamine receptor D3
Macaque
dopamine receptor D3
Mouse
Rat
Dog
dopamine receptor D3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35462-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Dopamine receptors
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
Dopamine receptors
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (64)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (330)
1 – 10 of 330
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.966
Data Source: STRINGDB
PDYN
Tbio
Novelty: 0.00039564
Score: 0.964
Data Source: STRINGDB
GRM2
Tchem
Family: GPCR
Novelty: 0.00132156
Score: 0.953
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.951
Data Source: STRINGDB
PENK
Tbio
Novelty: 0.00074167
Score: 0.95
Data Source: STRINGDB
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.95
Data Source: STRINGDB
CNR2
Tchem
Family: GPCR
Novelty: 0.00215391
Score: 0.95
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.948
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.948
Data Source: STRINGDB
ADCY5
Tchem
Family: Enzyme
Novelty: 0.00307839
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  412.73

PubMed score by year
PubTator Score  372.01

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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