Protein Summary
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By simi ...more
- ENST00000350881
- ENSP00000339730
- ENSG00000113296
- TSP4
- TSP4
- TSP-4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
PubMedID | 0.81 | ||
biological process | 0.8 | ||
gene perturbation | 0.76 | ||
disease | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.03 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 161 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.03 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 161 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (65)
Nearest Tclin Targets
Pathways (12)
Reactome (3)
KEGG (6)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Signal Transduction | ||||
Reactome | Signaling by PDGF | ||||
Reactome | Signaling by Receptor Tyrosine Kinases | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Signal Transduction | ||||
Signaling by PDGF | ||||
Signaling by Receptor Tyrosine Kinases | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (4)
Components (7)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
corneal topography | 2 | 1 | 2 | 74.8 | |||||
intraocular pressure measurement | 1 | 2 | 2 | 60.1 | |||||
smoking status measurement | 2 | 1 | 2 | 45.7 | |||||
central corneal thickness | 1 | 1 | 0 | 2.4 | 0.9 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
corneal topography | 2 | 74.8 | |||||
intraocular pressure measurement | 2 | 60.1 | |||||
smoking status measurement | 2 | 45.7 | |||||
central corneal thickness | 0 | 2.4 | 0.9 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | thrombospondin 4 | VGNC:4195 | 450172 | |||||
Macaque | thrombospondin 4 | 574276 | ||||||
Mouse | MGI:1101779 | 21828 | ||||||
Rat | RGD:62046 | 29220 | ||||||
Dog | thrombospondin 4 | VGNC:47338 | 488930 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | thrombospondin 4 | |||||
Macaque | thrombospondin 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | thrombospondin 4 | |||||
Publication Statistics
PubMed Score 132.03
PubMed score by year
PubTator Score 57.14
PubTator score by year
Related Publications
Text Mined References (62)
GeneRif Annotations (27)
Items per page:
0 of 0
PMID | Year | Title |
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