Tbio THBS4 Thrombospondin-4

Protein Summary

Description

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity). The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Accession IDs

• P35443
• B2R909
• Q86TG2

Gene Name

• THBS4

Ensembl ID

• ENST00000350881
• ENSP00000339730
• ENSG00000113296

Symbol

• TSP4
• TSP4
• TSP-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
PubMedID	0.81
biological process	0.8
gene perturbation	0.76
disease	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.03   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.03   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (65)

Explore Interacting Targets

1 – 10 of 65

• See Interactions on String-DB

THBS3

Tbio

Novelty:  0.01915634

p_int:  0.999975769

p_wrong:  0.000024231

Score:  0.24

Data Source:  BioPlex,STRINGDB

MATN2

Tbio

Novelty:  0.08506252

p_int:  0.99567822

p_ni:  1.2e-8

p_wrong:  0.004321768

Score:  0.294

Data Source:  BioPlex,STRINGDB

PDGFB

Tbio

Novelty:  0.00080876

Score:  0.905

Data Source:  Reactome,STRINGDB

CD47

Tchem

Novelty:  0.00129086

Score:  0.894

Data Source:  STRINGDB

CD36

Tbio

Novelty:  0.00140825

Score:  0.824

Data Source:  STRINGDB

ITGA2

Tbio

Novelty:  0.0013482

Score:  0.731

Data Source:  STRINGDB

ITGA9

Tbio

Novelty:  0.01488635

Score:  0.721

Data Source:  STRINGDB

ITGA1

Tbio

Novelty:  0.00545805

Score:  0.714

Data Source:  STRINGDB

CXCR2

Tchem

Family:  GPCR

Novelty:  0.00108314

Score:  0.711

Data Source:  STRINGDB

ITGA6

Tbio

Novelty:  0.00217985

Score:  0.696

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (12)

Reactome (3)

KEGG (6)

WikiPathways (3)

Signal Transduction (R-HSA-162582)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by PDGF	53 targets	R-HSA-186797
Reactome	Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934

Name	Explore in Pharos	Explore in Source
Signal Transduction	2704 targets	R-HSA-162582
Signaling by PDGF	53 targets	R-HSA-186797
Signaling by Receptor Tyrosine Kinases	455 targets	R-HSA-9006934

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (4)

Components (7)

Processes (12)

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1 – 4 of 4

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
heparin binding	Inferred from Direct Assay (IDA)	UniProtKB
integrin binding	Inferred from Direct Assay (IDA)	UniProtKB
growth factor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (4)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
corneal topography	EFO_0004345	2	1	2		74.8
intraocular pressure measurement	EFO_0004695	1	2	2		60.1
smoking status measurement	EFO_0006527	2	1	2		45.7
central corneal thickness	EFO_0005213	1	1	0	2.4	0.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
corneal topography	EFO_0004345	2		74.8
intraocular pressure measurement	EFO_0004695	2		60.1
smoking status measurement	EFO_0006527	2		45.7
central corneal thickness	EFO_0005213	0	2.4	0.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Calcium
Cell adhesion
Complete proteome
Disulfide bond
EGF-like domain
Endoplasmic reticulum
Extracellular matrix
Glycoprotein
Growth factor
Mitogen

GWAS Trait Find Similar Targets

No Header	No Header
central corneal thickness
corneal topography
intraocular pressure measurement
smoking status measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	thrombospondin 4	VGNC:4195	450172
Macaque	thrombospondin 4		574276
Mouse	thrombospondin 4	MGI:1101779	21828
Rat	thrombospondin 4	RGD:62046	29220
Dog	thrombospondin 4	VGNC:47338	488930

Species	Name	OMA	EggNOG	Inparanoid
Chimp	thrombospondin 4
Macaque	thrombospondin 4
Mouse	thrombospondin 4
Rat	thrombospondin 4
Dog	thrombospondin 4

Publication Statistics

PubMed Score 132.03

PubMed score by year

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PubTator Score 57.14

PubTator score by year

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Related Publications

Text Mined References (62)

GeneRif Annotations (27)

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PMID	Year	Title