Protein Summary
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
- ENST00000366787
- ENSP00000355751
- ENSG00000186340
- ENST00000617924
- ENSP00000482784
- TSP2
- TSP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
PubMedID | 0.92 | ||
small molecule perturbation | 0.67 | ||
gene perturbation | 0.64 | ||
cell type or tissue | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 374.22 (req: < 5)
Gene RIFs: 65 (req: <= 3)
Antibodies: 220 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 374.22 (req: >= 5)
Gene RIFs: 65 (req: > 3)
Antibodies: 220 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (171)
DPY19L3
Family: Enzyme
Novelty: 0.35244121
p_int: 0.999994868
p_ni: 0.000004949
p_wrong: 1.83e-7
Score: 0.194
Data Source: BioPlex,STRINGDB
B3GLCT
Family: Enzyme
Novelty: 0.02398944
p_int: 0.999964356
p_ni: 0.000035643
p_wrong: 1e-9
Score: 0.948
Data Source: BioPlex,STRINGDB
PPP1R21
Family: Enzyme
Novelty: 0.33099657
p_int: 0.997022826
p_ni: 0.00297715
p_wrong: 2.4e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
PIGA
Family: Enzyme
Novelty: 0.00172769
p_int: 0.986956731
p_ni: 0.013043269
Data Source: BioPlex
AP1G2
Novelty: 0.17203425
p_int: 0.985939374
p_ni: 0.014060626
Score: 0.173
Data Source: BioPlex,STRINGDB
EDEM2
Family: Enzyme
Novelty: 0.1180208
p_int: 0.960075958
p_ni: 0.039924042
Data Source: BioPlex
FOXF2
Family: TF
Novelty: 0.02032168
p_int: 0.927673764
p_ni: 0.010344012
p_wrong: 0.061982224
Score: 0.218
Data Source: BioPlex,STRINGDB
ZNF696
Family: TF
Novelty: 3.49300122
p_int: 0.8717427
p_ni: 0.128250233
p_wrong: 0.000007067
Score: 0.169
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (29)
Reactome (11)
KEGG (6)
PathwayCommons (2)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (5)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
central corneal thickness | 1 | 1 | 0 | 1.5 | 10.4 | ||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
central corneal thickness | 0 | 1.5 | 10.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:98738 | 21826 | ||||||
Rat | RGD:1310979 | 292406 | ||||||
Dog | thrombospondin 2 | VGNC:47336 | 484087 | |||||
Horse | thrombospondin 2 | VGNC:24073 | 100050044 | |||||
Cow | thrombospondin 2 | VGNC:35829 | 338092 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | thrombospondin 2 | |||||
Horse | thrombospondin 2 | |||||
Cow | thrombospondin 2 | |||||
Publication Statistics
PubMed Score 374.22
PubMed score by year
PubTator Score 185.96
PubTator score by year
Related Publications
Text Mined References (95)
GeneRif Annotations (65)
Items per page:
0 of 0
PMID | Year | Title |
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