You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
APLNR
Apelin receptor

Protein Summary
Description
Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:110901 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257254
  • ENSP00000257254
  • ENSG00000134817
  • ENST00000606794
  • ENSP00000475344
  • ENST00000611099
  • ENSP00000477818

Symbol
  • AGTRL1
  • APJ
  • APJ
  • APJR
  • HG11
  • AGTRL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
biological term
0.62
tissue sample
0.61
protein domain
0.58
ligand (chemical)
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 473.53   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 517   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 473.53   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 102
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (362)
AKR1D1
Tbio
Family:  Enzyme
Novelty:  0.01264297
p_int:  0.999984238
p_ni:  0.000015762
Data Source:  BioPlex
TTI2
Tdark
Novelty:  0.18394695
p_int:  0.999698678
p_ni:  0.000286428
p_wrong:  0.000014894
Data Source:  BioPlex
MCUB
Tbio
Novelty:  0.0486243
p_int:  0.999471081
p_ni:  0.000528919
Data Source:  BioPlex
SLC25A24
Tbio
Family:  Transporter
Novelty:  0.06151955
p_int:  0.999409021
p_ni:  0.000590972
p_wrong:  6e-9
Data Source:  BioPlex
ORC5
Tbio
Novelty:  0.02264865
p_int:  0.998716289
p_ni:  0.001283698
p_wrong:  1.3e-8
Data Source:  BioPlex
TMEM161B
Tbio
Novelty:  0.27823549
p_int:  0.998468655
p_ni:  0.001531338
p_wrong:  8e-9
Data Source:  BioPlex
PDS5B
Tbio
Novelty:  0.00295057
p_int:  0.996954768
p_ni:  0.003045232
Data Source:  BioPlex
ABCD1
Tbio
Family:  Transporter
Novelty:  0.0067013
p_int:  0.996502309
p_ni:  0.003412851
p_wrong:  0.00008484
Data Source:  BioPlex
ADCK1
Tchem
Family:  Kinase
Novelty:  0.31158074
p_int:  0.996376839
p_ni:  0.003622713
p_wrong:  4.47e-7
Data Source:  BioPlex
HIP1R
Tbio
Novelty:  0.02502713
p_int:  0.995500592
p_ni:  0.004499408
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
53.3
apolipoprotein A 1 measurement
1
1
1
11.6
high density lipoprotein cholesterol measurement
1
1
1
7.8
heel bone mineral density
1
1
1
6.7
body mass index
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
53.3
apolipoprotein A 1 measurement
1
11.6
high density lipoprotein cholesterol measurement
1
7.8
heel bone mineral density
1
6.7
body mass index
1
2.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apelin receptor
VGNC:53053
466585
Macaque
apelin receptor
706823
Mouse
MGI:1346086
23796
Rat
RGD:621645
83518
Dog
apelin receptor
VGNC:37987
483497
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apelin receptor
Macaque
apelin receptor
Mouse
Rat
Dog
apelin receptor
Publication Statistics
PubMed Score 473.53
PubMed score by year
PubTator Score 199.84
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title