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Tchem
APLNR
Apelin receptor

Protein Summary
Description
Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:110901 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257254
  • ENSP00000257254
  • ENSG00000134817
  • ENST00000606794
  • ENSP00000475344
  • ENST00000611099
  • ENSP00000477818

Symbol
  • AGTRL1
  • APJ
  • APJ
  • APJR
  • HG11
  • AGTRL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
biological term
0.62
tissue sample
0.61
protein domain
0.58
ligand (chemical)
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 452.7   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 517   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 452.7   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
8.6
apolipoprotein A 1 measurement
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
8.6
apolipoprotein A 1 measurement
1
3.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apelin receptor
VGNC:53053
466585
Macaque
apelin receptor
706823
Mouse
MGI:1346086
23796
Rat
RGD:621645
83518
Dog
apelin receptor
VGNC:37987
483497
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apelin receptor
Macaque
apelin receptor
Mouse
Rat
Dog
apelin receptor
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35414-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (362)
1 – 10 of 362
AKR1D1
Tbio
Family: Enzyme
Novelty: 0.01264297
p_int: 0.999984238
p_ni: 0.000015762
Data Source: BioPlex
TTI2
Tdark
Novelty: 0.18394695
p_int: 0.999698678
p_ni: 0.000286428
p_wrong: 0.000014894
Data Source: BioPlex
MCUB
Tbio
Novelty: 0.0486243
p_int: 0.999471081
p_ni: 0.000528919
Data Source: BioPlex
SLC25A24
Tbio
Family: Transporter
Novelty: 0.06151955
p_int: 0.999409021
p_ni: 0.000590972
p_wrong: 6e-9
Data Source: BioPlex
ORC5
Tbio
Novelty: 0.02264865
p_int: 0.998716289
p_ni: 0.001283698
p_wrong: 1.3e-8
Data Source: BioPlex
TMEM161B
Tbio
Novelty: 0.27823549
p_int: 0.998468655
p_ni: 0.001531338
p_wrong: 8e-9
Data Source: BioPlex
PDS5B
Tbio
Novelty: 0.00295057
p_int: 0.996954768
p_ni: 0.003045232
Data Source: BioPlex
ABCD1
Tbio
Family: Transporter
Novelty: 0.0067013
p_int: 0.996502309
p_ni: 0.003412851
p_wrong: 0.00008484
Data Source: BioPlex
ADCK1
Tdark
Family: Kinase
Novelty: 0.31158074
p_int: 0.996376839
p_ni: 0.003622713
p_wrong: 4.47e-7
Data Source: BioPlex
HIP1R
Tbio
Novelty: 0.02502713
p_int: 0.995500592
p_ni: 0.004499408
Data Source: BioPlex
Publication Statistics
PubMed Score  452.70

PubMed score by year
PubTator Score  199.84

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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