Protein Summary
Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:110901 ...more
- ENST00000257254
- ENSP00000257254
- ENSG00000134817
- ENST00000606794
- ENSP00000475344
- ENST00000611099
- ENSP00000477818
- AGTRL1
- APJ
- APJ
- APJR
- HG11
- AGTRL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.7 | ||
biological term | 0.62 | ||
tissue sample | 0.61 | ||
protein domain | 0.58 | ||
ligand (chemical) | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 473.53 (req: < 5)
Gene RIFs: 72 (req: <= 3)
Antibodies: 517 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 473.53 (req: >= 5)
Gene RIFs: 72 (req: > 3)
Antibodies: 517 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 102
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (102)
Protein-Protein Interactions (362)
AKR1D1
Family: Enzyme
Novelty: 0.01264297
p_int: 0.999984238
p_ni: 0.000015762
Data Source: BioPlex
TTI2
Novelty: 0.18394695
p_int: 0.999698678
p_ni: 0.000286428
p_wrong: 0.000014894
Data Source: BioPlex
SLC25A24
Family: Transporter
Novelty: 0.06151955
p_int: 0.999409021
p_ni: 0.000590972
p_wrong: 6e-9
Data Source: BioPlex
ORC5
Novelty: 0.02264865
p_int: 0.998716289
p_ni: 0.001283698
p_wrong: 1.3e-8
Data Source: BioPlex
TMEM161B
Novelty: 0.27823549
p_int: 0.998468655
p_ni: 0.001531338
p_wrong: 8e-9
Data Source: BioPlex
ABCD1
Family: Transporter
Novelty: 0.0067013
p_int: 0.996502309
p_ni: 0.003412851
p_wrong: 0.00008484
Data Source: BioPlex
ADCK1
Family: Kinase
Novelty: 0.31158074
p_int: 0.996376839
p_ni: 0.003622713
p_wrong: 4.47e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (10)
Reactome (7)
KEGG (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (2)
Components (2)
Processes (13)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 53.3 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 11.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 7.8 | |||||
heel bone mineral density | 1 | 1 | 1 | 6.7 | |||||
body mass index | 1 | 1 | 1 | 2.6 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 53.3 | |||||
apolipoprotein A 1 measurement | 1 | 11.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 7.8 | |||||
heel bone mineral density | 1 | 6.7 | |||||
body mass index | 1 | 2.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | apelin receptor | VGNC:53053 | 466585 | |||||
Macaque | apelin receptor | 706823 | ||||||
Mouse | MGI:1346086 | 23796 | ||||||
Rat | RGD:621645 | 83518 | ||||||
Dog | apelin receptor | VGNC:37987 | 483497 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | apelin receptor | |||||
Macaque | apelin receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | apelin receptor | |||||
Publication Statistics
PubMed Score 473.53
PubMed score by year
PubTator Score 199.84
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (88)
GeneRif Annotations (72)
Items per page:
0 of 0
PMID | Year | Title |
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