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Tclin
PTGER4
Prostaglandin E2 receptor EP4 subtype

Protein Summary
Description
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302472
  • ENSP00000302846
  • ENSG00000171522

Symbol
  • PTGER2
  • EP4
  • EP4R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
gene perturbation
0.97
ligand (chemical)
0.97
biological process
0.94


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1297.9   (req: < 5)
Gene RIFs: 118   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1297.9   (req: >= 5)
Gene RIFs: 118   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 368
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E receptor 4
VGNC:4139
450195
Macaque
prostaglandin E receptor 4
695220
Mouse
MGI:104311
19219
Rat
RGD:628641
84023
Dog
prostaglandin E receptor 4
VGNC:45144
403589
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E receptor 4
Macaque
prostaglandin E receptor 4
Mouse
Rat
Dog
prostaglandin E receptor 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35408-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (25)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (204)
1 – 10 of 204
CRH
Tbio
Novelty: 0.000147
Score: 0.932
Data Source: STRINGDB
PTH
Tbio
Novelty: 0.00003263
Score: 0.932
Data Source: STRINGDB
AVPR2
Tclin
Family: GPCR
Novelty: 0.0009139
Score: 0.928
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.927
Data Source: STRINGDB
PTGER2
Tclin
Family: GPCR
Novelty: 0.0206174
Score: 0.927
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.927
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.927
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.927
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.926
Data Source: STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  1297.90

PubMed score by year
PubTator Score  478.39

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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