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Tclin
PTGER4
Prostaglandin E2 receptor EP4 subtype

Protein Summary
Description
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302472
  • ENSP00000302846
  • ENSG00000171522

Symbol
  • PTGER2
  • EP4
  • EP4R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
gene perturbation
0.97
ligand (chemical)
0.97
biological process
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1318.93   (req: < 5)
Gene RIFs: 118   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1318.93   (req: >= 5)
Gene RIFs: 118   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 466
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (204)
CRH
Tbio
Novelty:  0.000147
Score:  0.932
Data Source:  STRINGDB
PTH
Tbio
Novelty:  0.00003263
Score:  0.932
Data Source:  STRINGDB
AVPR2
Tclin
Family:  GPCR
Novelty:  0.0009139
Score:  0.928
Data Source:  STRINGDB
P84996
Tbio
Novelty:  0.00284739
Score:  0.927
Data Source:  STRINGDB
PTGER2
Tclin
Family:  GPCR
Novelty:  0.0206174
Score:  0.927
Data Source:  STRINGDB
O95467
Tbio
Novelty:  0.00284739
Score:  0.927
Data Source:  STRINGDB
Q5JWF2
Tbio
Novelty:  0.00284739
Score:  0.927
Data Source:  STRINGDB
P63092
Tbio
Novelty:  0.00284739
Score:  0.927
Data Source:  STRINGDB
P01258
Tbio
Novelty:  0.00010496
Score:  0.926
Data Source:  STRINGDB
P06881
Tclin
Novelty:  0.00010496
Score:  0.926
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
2
3
3
97.8
blood urea nitrogen measurement
2
2
2
94.7
6
3
0
1.3
92.2
hemoglobin measurement
3
2
3
73.4
hematocrit
2
2
2
68.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum urea measurement
3
97.8
blood urea nitrogen measurement
2
94.7
0
1.3
92.2
hemoglobin measurement
3
73.4
hematocrit
2
68.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E receptor 4
VGNC:4139
450195
Macaque
prostaglandin E receptor 4
695220
Mouse
MGI:104311
19219
Rat
RGD:628641
84023
Dog
prostaglandin E receptor 4
VGNC:45144
403589
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E receptor 4
Macaque
prostaglandin E receptor 4
Mouse
Rat
Dog
prostaglandin E receptor 4
Publication Statistics
PubMed Score 1318.93
PubMed score by year
PubTator Score 478.39
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title