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Tchem
RORA
Nuclear receptor ROR-alpha

Protein Summary
Description
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development (PubMed:29656859). Regulates SHH gene expression, among others, to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261523
  • ENSP00000261523
  • ENSG00000069667
  • ENST00000335670
  • ENSP00000335087

Symbol
  • NR1F1
  • RZRA
  • ROR1
  • ROR2
  • ROR3
  • RZRA
  • NR1F1
  • IDDECA
  • RZR-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
trait
1
transcription factor perturbation
1
biological process
0.99
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.55   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 523   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.55   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 523   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (29)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
Cytokine Signaling in Immune system
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Circadian Clock
Cytokine Signaling in Immune system
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Gene Ontology Terms (49)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (89)
1 – 10 of 89
ARNTL
Tbio
Family: TF
Novelty: 0.00130179
Score: 0.985
Data Source: STRINGDB
NPAS2
Tbio
Family: TF
Novelty: 0.01102244
Score: 0.978
Data Source: STRINGDB
CLOCK
Tbio
Family: TF; Epigenetic
Novelty: 0.00211154
Score: 0.966
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00060382
Score: 0.958
Data Source: Reactome,STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00013496
Score: 0.937
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.01259825
Score: 0.936
Data Source: STRINGDB
NRIP1
Tbio
Novelty: 0.00621822
Score: 0.934
Data Source: Reactome,STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.00288779
Score: 0.927
Data Source: STRINGDB
NR1D1
Tchem
Family: NR
Novelty: 0.00579481
Score: 0.926
Data Source: STRINGDB
HIF1A
Tchem
Family: TF
Novelty: 0.00031917
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  182.55

PubMed score by year
PubTator Score  187.03

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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