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Tchem
RORA
Nuclear receptor ROR-alpha

Protein Summary
Description
Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development (PubMed:29656859). Regulates SHH gene expression, among others, to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261523
  • ENSP00000261523
  • ENSG00000069667
  • ENST00000335670
  • ENSP00000335087

Symbol
  • NR1F1
  • RZRA
  • ROR1
  • ROR2
  • ROR3
  • RZRA
  • NR1F1
  • IDDECA
  • RZR-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
trait
1
transcription factor perturbation
1
biological process
0.99
molecular function
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.83   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 523   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.83   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 523   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (49)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
6
11
13
4.5
99.7
C-reactive protein measurement
5
5
7
97.5
8
5
0
1.1
93.7
balding measurement
2
6
6
93
3
2
0
1.1
87.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
13
4.5
99.7
C-reactive protein measurement
7
97.5
0
1.1
93.7
balding measurement
6
93
0
1.1
87.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAR related orphan receptor A
704014
Mouse
MGI:104661
19883
Dog
RAR related orphan receptor A
VGNC:45695
478328
Horse
RAR related orphan receptor A
VGNC:51673
100147460
Cow
RAR related orphan receptor A
VGNC:34088
535597
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAR related orphan receptor A
Mouse
Dog
RAR related orphan receptor A
Horse
RAR related orphan receptor A
Cow
RAR related orphan receptor A
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35398-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Circadian Clock (R-HSA-400253)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Circadian Clock
Reactome
Cytokine Signaling in Immune system
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Circadian Clock
Cytokine Signaling in Immune system
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Gene Ontology Terms (49)
Items per page:
10
1 – 10 of 16
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (89)
1 – 10 of 89
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
Score:  0.985
Data Source:  STRINGDB
NPAS2
Tbio
Family:  TF
Novelty:  0.00728451
Score:  0.978
Data Source:  STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
Score:  0.966
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.958
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.937
Data Source:  STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.936
Data Source:  STRINGDB
NRIP1
Tbio
Novelty:  0.00551568
Score:  0.934
Data Source:  Reactome,STRINGDB
NCOR1
Tchem
Family:  TF
Novelty:  0.0021926
Score:  0.927
Data Source:  STRINGDB
NR1D1
Tchem
Family:  NR
Novelty:  0.00250799
Score:  0.926
Data Source:  STRINGDB
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
Score:  0.924
Data Source:  STRINGDB
Publication Statistics
PubMed Score  243.83

PubMed score by year
PubTator Score  187.03

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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