Pharos : Target Details

Tclin

Protein Classes

Protein Summary

Description

Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:7905839, PubMed:7957926, PubMed:7891175, PubMed:12589820, PubMed:9689128). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, includi ...more

Uniprot Accession IDs

Gene Name

OPRM1

Ensembl ID

ENST00000229768
ENSP00000229768
ENSG00000112038
ENST00000330432
ENSP00000328264
ENST00000337049
ENSP00000338381
ENST00000414028
ENSP00000399359
ENST00000419506
ENSP00000403549
ENST00000428397
ENSP00000411903
ENST00000434900
ENSP00000394624
ENST00000435918
ENSP00000413752
ENST00000452687
ENSP00000410497
ENST00000518759
ENSP00000430260
ENST00000519083
ENSP00000431048
ENST00000520708
ENSP00000430876
ENST00000522236
ENSP00000429373
ENST00000522555
ENSP00000429719
ENST00000522739
ENSP00000428018
ENST00000524150
ENSP00000430575
ENST00000524163
ENSP00000430097

Symbol

MOR1
MOP
MOR
LMOR
MOR1
OPRM
M-OR-1

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1

molecular function	1

biological process	0.99

ligand (chemical)	0.99

kinase	0.96

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2654.46 (req: < 5)

View Publications

Gene RIFs: 402 (req: <= 3)

View Gene RIFs

Antibodies: 512 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2654.46 (req: >= 5)

Gene RIFs: 402 (req: > 3)

Antibodies: 512 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2083

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 40

Explore Approved Drugs

Approved Drugs (40)

1 – 10 of 40

Active Ligands (2083)

1 – 10 of 2083

CHEMBL3912511,CHEMBL3916122

CHEMBL147511

CHEMBL13470

CHEMBL3759660,CHEMBL242756

GWAS Traits (6)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
opioid use disorder	EFO_0010702	1	1	1		72.2

chronic lymphocytic leukemia	EFO_0000095	2	2	0	1.2	65.6

testosterone measurement	EFO_0004908	1	1	1		56.7

diastolic blood pressure	EFO_0006336	1	1	1		37.5

body height	EFO_0004339	1	1	1		22.2

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
opioid use disorder	EFO_0010702	1		72.2

chronic lymphocytic leukemia	EFO_0000095	0	1.2	65.6

testosterone measurement	EFO_0004908	1		56.7

diastolic blood pressure	EFO_0006336	1		37.5

body height	EFO_0004339	1		22.2

Beta Count

Odds Ratio

Pathways (28)

Reactome (18)

KEGG (3)

PathwayCommons (4)

WikiPathways (3)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076

Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594

Reactome	G-protein activation	28 targets	R-HSA-202040

Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076

Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

G alpha (i) signalling events	408 targets	R-HSA-418594

G-protein activation	28 targets	R-HSA-202040

GPCR downstream signalling	1152 targets	R-HSA-388396

Gene Ontology Terms (65)

Functions (10)

Components (17)

Processes (38)

Items per page:

1 – 10 of 10

GO Term	Evidence	Assigned by
G-protein alpha-subunit binding	Inferred from Direct Assay (IDA)	UniProtKB

beta-endorphin receptor activity	Inferred from Mutant Phenotype (IMP)	UniProtKB

G-protein beta-subunit binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

neuropeptide binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

G protein-coupled receptor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

morphine receptor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

voltage-gated calcium channel activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

filamin binding	Inferred from Electronic Annotation (IEA)	Ensembl

protein C-terminus binding	Inferred from Electronic Annotation (IEA)	Ensembl

protein domain specific binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (456)

1 – 10 of 456

See Interactions on String-DB

ZFYVE26

Tbio

Novelty: 0.04897973

p_int: 0.999799451

p_ni: 0.000007509

p_wrong: 0.00019304

Score: 0.239

Data Source: BioPlex,STRINGDB

MMS22L

Tbio

Novelty: 0.22570578

p_int: 0.9990965

p_ni: 0.000899655

p_wrong: 0.000003845

Data Source: BioPlex

THADA

Tbio

Novelty: 0.06983966

p_int: 0.99831819

p_ni: 0.00168181

Data Source: BioPlex

LPCAT3

Tbio

Family: Enzyme

Novelty: 0.00485213

p_int: 0.997624847

p_ni: 0.002373546

p_wrong: 0.000001607

Data Source: BioPlex

XPO6

Tbio

Novelty: 0.03229708

p_int: 0.997547629

p_ni: 0.00245237

Data Source: BioPlex

XPO4

Tbio

Novelty: 0.01507446

p_int: 0.996145393

p_ni: 0.003854607

Data Source: BioPlex

HTT

Tchem

Novelty: 0.00034051

p_int: 0.996145315

p_ni: 0.003854685

Score: 0.219

Data Source: BioPlex,STRINGDB

BRAT1

Tbio

Novelty: 0.04039173

p_int: 0.995213743

p_ni: 0.004786256

Data Source: BioPlex

MZT2B

Tdark

Novelty: 0.69469786

p_int: 0.994954521

p_ni: 0.004100907

p_wrong: 0.000944572

Data Source: BioPlex

TUBGCP2

Tbio

Novelty: 0.01856674

p_int: 0.994884016

p_ni: 0.005115984

Data Source: BioPlex

Publication Statistics

PubMed Score 2654.46

PubMed score by year

PubTator Score 1250.74

PubTator score by year

Patents

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword


Alternative splicing

Cell membrane

Cell projection

Complete proteome

Cytoplasm

Disulfide bond

Endosome

G-protein coupled receptor

Glycoprotein

Lipoprotein

GWAS Trait

MGI Phenotype


adipose tissue phenotype

behavior/neurological phenotype

cellular phenotype

digestive/alimentary phenotype

endocrine/exocrine gland phenotype

growth/size/body region phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

immune system phenotype

integument phenotype