Protein Classes
Protein Summary
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:7905839, PubMed:7957926, PubMed:7891175, PubMed:12589820, PubMed:9689128). Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839). The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084). They mediate an array of downstream cellular responses, includi ...more
- ENST00000229768
- ENSP00000229768
- ENSG00000112038
- ENST00000330432
- ENSP00000328264
- ENST00000337049
- ENSP00000338381
- ENST00000414028
- ENSP00000399359
- ENST00000419506
- ENSP00000403549
- ENST00000428397
- ENSP00000411903
- ENST00000434900
- ENSP00000394624
- ENST00000435918
- ENSP00000413752
- ENST00000452687
- ENSP00000410497
- ENST00000518759
- ENSP00000430260
- ENST00000519083
- ENSP00000431048
- ENST00000520708
- ENSP00000430876
- ENST00000522236
- ENSP00000429373
- ENST00000522555
- ENSP00000429719
- ENST00000522739
- ENSP00000428018
- ENST00000524150
- ENSP00000430575
- ENST00000524163
- ENSP00000430097
- MOR1
- MOP
- MOR
- LMOR
- MOR1
- OPRM
- M-OR-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
drug | 1 | ||
molecular function | 1 | ||
biological process | 0.99 | ||
ligand (chemical) | 0.99 | ||
kinase | 0.96 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2655.39 (req: < 5)
Gene RIFs: 402 (req: <= 3)
Antibodies: 512 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2655.39 (req: >= 5)
Gene RIFs: 402 (req: > 3)
Antibodies: 512 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 48
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2083
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 40
Approved Drugs (40)
1 – 10 of 40
Active Ligands (2083)
1 – 10 of 2083
Pathways (28)
Reactome (18)
KEGG (3)
PathwayCommons (4)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 18
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | G-protein activation | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
Cytokine Signaling in Immune system | ||||
G alpha (i) signalling events | ||||
G-protein activation | ||||
GPCR downstream signalling | ||||
Gene Ontology Terms (65)
Functions (10)
Components (17)
Processes (38)
Items per page:
10
1 – 10 of 10
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (456)
1 – 10 of 456
ZFYVE26
Novelty: 0.06952817
p_int: 0.999799451
p_ni: 0.000007509
p_wrong: 0.00019304
Score: 0.239
Data Source: BioPlex,STRINGDB
MMS22L
Novelty: 0.35674616
p_int: 0.9990965
p_ni: 0.000899655
p_wrong: 0.000003845
Data Source: BioPlex
THADA
Novelty: 0.02734274
p_int: 0.99831819
p_ni: 0.00168181
Data Source: BioPlex
LPCAT3
Family: Enzyme
Novelty: 0.00564842
p_int: 0.997624847
p_ni: 0.002373546
p_wrong: 0.000001607
Data Source: BioPlex
XPO6
Novelty: 0.0244998
p_int: 0.997547629
p_ni: 0.00245237
Data Source: BioPlex
XPO4
Novelty: 0.02272837
p_int: 0.996145393
p_ni: 0.003854607
Data Source: BioPlex
HTT
Novelty: 0.00040613
p_int: 0.996145315
p_ni: 0.003854685
Score: 0.219
Data Source: BioPlex,STRINGDB
BRAT1
Novelty: 0.04085239
p_int: 0.995213743
p_ni: 0.004786256
Data Source: BioPlex
MZT2B
Novelty: 4
p_int: 0.994954521
p_ni: 0.004100907
p_wrong: 0.000944572
Data Source: BioPlex
TUBGCP2
Novelty: 0.03216604
p_int: 0.994884016
p_ni: 0.005115984
Data Source: BioPlex
Publication Statistics
PubMed Score 2655.39
PubMed score by year
PubTator Score 1250.74
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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