Protein Classes
Protein Summary
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pa ...more
- ENST00000397056
- ENSP00000380247
- ENSG00000196639
- ENST00000431010
- ENSP00000397028
- ENST00000438284
- ENSP00000406705
- H1R
- H1-R
- HH1R
- hisH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
ligand (chemical) | 1 | ||
biological process | 0.89 | ||
virus perturbation | 0.88 | ||
chemical | 0.8 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1050.53 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 508 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1050.53 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 508 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 458
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 91
Approved Drugs (91)
1 – 10 of 91
Active Ligands (458)
1 – 10 of 458
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (16)
Reactome (8)
KEGG (3)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Gene Ontology Terms (22)
Functions (4)
Components (4)
Processes (14)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Protein-Protein Interactions (193)
1 – 10 of 193
TAC1
Novelty: 0.00007711
Score: 0.953
Data Source: STRINGDB
KNG1
Novelty: 0.00008572
Score: 0.949
Data Source: STRINGDB
BDKRB2
Family: GPCR
Novelty: 0.00504032
Score: 0.946
Data Source: STRINGDB
HCRT
Novelty: 0.00044523
Score: 0.943
Data Source: STRINGDB
NPS
Novelty: 0.00011983
Score: 0.941
Data Source: STRINGDB
GRPR
Family: GPCR
Novelty: 0.00322431
Score: 0.941
Data Source: STRINGDB
ARHGEF25
Novelty: 0.0351143
Score: 0.937
Data Source: STRINGDB
TBXA2R
Family: GPCR
Novelty: 0.00629658
Score: 0.935
Data Source: STRINGDB
NTS
Novelty: 0.00035891
Score: 0.934
Data Source: STRINGDB
GRP
Novelty: 0.00039263
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score 1050.53
PubMed score by year
PubTator Score 624.42
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
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