Protein Summary
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pa ...more
- ENST00000397056
- ENSP00000380247
- ENSG00000196639
- ENST00000431010
- ENSP00000397028
- ENST00000438284
- ENSP00000406705
- H1R
- H1-R
- HH1R
- hisH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
ligand (chemical) | 1 | ||
biological process | 0.89 | ||
virus perturbation | 0.88 | ||
chemical | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1351.4 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 508 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1351.4 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 508 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 687
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 94
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (94)
Active Ligands (687)
Protein-Protein Interactions (193)
Nearest Tclin Targets
Pathways (16)
Reactome (8)
KEGG (3)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (4)
Components (4)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 3 | 4 | 91.9 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 68.3 | |||||
BMI-adjusted hip circumference | 1 | 2 | 2 | 59.4 | |||||
hip circumference | 1 | 1 | 1 | 39.6 | |||||
appendicular lean mass | 1 | 1 | 1 | 27.3 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 4 | 91.9 | |||||
comparative body size at age 10, self-reported | 1 | 68.3 | |||||
BMI-adjusted hip circumference | 2 | 59.4 | |||||
hip circumference | 1 | 39.6 | |||||
appendicular lean mass | 1 | 27.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | histamine receptor H1 | VGNC:1838 | 470746 | |||||
Macaque | histamine receptor H1 | 696359 | ||||||
Mouse | MGI:107619 | 15465 | ||||||
Rat | RGD:2830 | 24448 | ||||||
Dog | histamine receptor H1 | VGNC:41786 | 403813 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | histamine receptor H1 | |||||
Macaque | histamine receptor H1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | histamine receptor H1 | |||||
Publication Statistics
PubMed Score 1351.40
PubMed score by year
PubTator Score 624.42
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (100)
GeneRif Annotations (70)
Items per page:
0 of 0
PMID | Year | Title |
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