Protein Classes
Protein Summary
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pa ...more
- ENST00000397056
- ENSP00000380247
- ENSG00000196639
- ENST00000431010
- ENSP00000397028
- ENST00000438284
- ENSP00000406705
- H1R
- H1-R
- HH1R
- hisH1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
ligand (chemical) | 1 | ||
biological process | 0.89 | ||
virus perturbation | 0.88 | ||
chemical | 0.8 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1333.39 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 508 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1333.39 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 508 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 458
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 91
Approved Drugs (91)
1 – 10 of 91
Active Ligands (458)
1 – 10 of 458
GWAS Traits (2)
Items per page:
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GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 2 | 2 | 94.2 | |||||
appendicular lean mass | 1 | 1 | 1 | 55 | |||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 94.2 | |||||
appendicular lean mass | 1 | 55 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | histamine receptor H1 | VGNC:1838 | 470746 | |||||
Macaque | histamine receptor H1 | 696359 | ||||||
Mouse | MGI:107619 | 15465 | ||||||
Rat | RGD:2830 | 24448 | ||||||
Dog | histamine receptor H1 | VGNC:41786 | 403813 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | histamine receptor H1 | |||||
Macaque | histamine receptor H1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | histamine receptor H1 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (16)
Reactome (8)
KEGG (3)
PathwayCommons (2)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amine ligand-binding receptors | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amine ligand-binding receptors | ||||
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Gene Ontology Terms (22)
Functions (4)
Components (4)
Processes (14)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Protein-Protein Interactions (193)
1 – 10 of 193
TAC1
Novelty: 0.00006575
Score: 0.953
Data Source: STRINGDB
KNG1
Novelty: 0.00007684
Score: 0.949
Data Source: STRINGDB
BDKRB2
Family: GPCR
Novelty: 0.00335227
Score: 0.946
Data Source: STRINGDB
HCRT
Novelty: 0.00034048
Score: 0.943
Data Source: STRINGDB
NPS
Novelty: 0.00692108
Score: 0.941
Data Source: STRINGDB
GRPR
Family: GPCR
Novelty: 0.00282511
Score: 0.941
Data Source: STRINGDB
ARHGEF25
Novelty: 0.02782136
Score: 0.937
Data Source: STRINGDB
TBXA2R
Family: GPCR
Novelty: 0.00571066
Score: 0.935
Data Source: STRINGDB
NTS
Novelty: 0.00033201
Score: 0.934
Data Source: STRINGDB
GRP
Novelty: 0.00034247
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score 1333.39
PubMed score by year
PubTator Score 624.42
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword