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Tclin
HRH1
Histamine H1 receptor

Protein Summary
Description
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397056
  • ENSP00000380247
  • ENSG00000196639
  • ENST00000431010
  • ENSP00000397028
  • ENST00000438284
  • ENSP00000406705

Symbol
  • H1R
  • H1-R
  • HH1R
  • hisH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
1
biological process
0.89
virus perturbation
0.88
chemical
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1333.39   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 508   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1333.39   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 458
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 91
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
94.2
appendicular lean mass
1
1
1
55
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
94.2
appendicular lean mass
1
55
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histamine receptor H1
VGNC:1838
470746
Macaque
histamine receptor H1
696359
Mouse
MGI:107619
15465
Rat
RGD:2830
24448
Dog
histamine receptor H1
VGNC:41786
403813
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histamine receptor H1
Macaque
histamine receptor H1
Mouse
Rat
Dog
histamine receptor H1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P35367-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (22)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (193)
1 – 10 of 193
TAC1
Tbio
Novelty: 0.00006575
Score: 0.953
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.949
Data Source: STRINGDB
BDKRB2
Tclin
Family: GPCR
Novelty: 0.00335227
Score: 0.946
Data Source: STRINGDB
HCRT
Tbio
Novelty: 0.00034048
Score: 0.943
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.941
Data Source: STRINGDB
GRPR
Tchem
Family: GPCR
Novelty: 0.00282511
Score: 0.941
Data Source: STRINGDB
ARHGEF25
Tbio
Novelty: 0.02782136
Score: 0.937
Data Source: STRINGDB
TBXA2R
Tclin
Family: GPCR
Novelty: 0.00571066
Score: 0.935
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.934
Data Source: STRINGDB
GRP
Tbio
Novelty: 0.00034247
Score: 0.933
Data Source: STRINGDB
Publication Statistics
PubMed Score  1333.39

PubMed score by year
PubTator Score  624.42

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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