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Tclin
PTGS2
Prostaglandin G/H synthase 2

Protein Summary
Description
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367468
  • ENSP00000356438
  • ENSG00000073756

Symbol
  • COX2
  • COX2
  • COX-2
  • PHS-2
  • PGG/HS
  • PGHS-2
  • hCox-2
  • GRIPGHS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
drug
1
gene perturbation
1


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15504.14   (req: < 5)
Gene RIFs: 1962   (req: <= 3)
Antibodies: 875   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15504.14   (req: >= 5)
Gene RIFs: 1962   (req: > 3)
Antibodies: 875   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 73
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1525
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 54
Approved Drugs (54)
1 – 10 of 54
celecoxib
chemical structure image
flufenamic acid
chemical structure image
valdecoxib
chemical structure image
indomethacin
chemical structure image
diclofenac
chemical structure image
mefenamic acid
chemical structure image
niflumic acid
chemical structure image
meclofenamic acid
chemical structure image
mesalazine
chemical structure image
ibuprofen
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin-endoperoxide synthase 2
VGNC:6970
469616
Macaque
prostaglandin-endoperoxide synthase 2
716671
Mouse
MGI:97798
19225
Rat
RGD:620349
29527
Dog
prostaglandin-endoperoxide synthase 2
VGNC:45152
442942
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin-endoperoxide synthase 2
Macaque
prostaglandin-endoperoxide synthase 2
Mouse
Rat
Dog
prostaglandin-endoperoxide synthase 2
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (65)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of DPA-derived SPMs
Reactome
Biosynthesis of DPAn-3 SPMs
Reactome
Biosynthesis of EPA-derived SPMs
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of DHA-derived SPMs
Biosynthesis of DPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Biosynthesis of EPA-derived SPMs
Gene Ontology Terms (81)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (500)
1 – 10 of 500
LMAN2L
Tbio
Novelty: 0.04364985
p_int: 1
Score: 0.351
Data Source: BioPlex,STRINGDB
PTGES
Tchem
Family: Enzyme
Novelty: 0.00146096
Score: 0.984
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.98
Data Source: STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
Score: 0.975
Data Source: STRINGDB
IL1B
Tclin
Novelty: 0.0000308
Score: 0.974
Data Source: STRINGDB
PTGIS
Tchem
Family: Enzyme
Novelty: 0.00183292
Score: 0.974
Data Source: STRINGDB
PTGDS
Tchem
Family: Enzyme
Novelty: 0.002111
Score: 0.968
Data Source: STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
Score: 0.967
Data Source: STRINGDB
CYP2E1
Tchem
Novelty: 0.00030504
Score: 0.964
Data Source: STRINGDB
ALOX15
Tchem
Family: Enzyme
Novelty: 0.00184734
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  15504.14

PubMed score by year
PubTator Score  8401.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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