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Tclin
ADRA1A
Alpha-1A adrenergic receptor

Protein Summary
Description
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276393
  • ENSP00000276393
  • ENSG00000120907
  • ENST00000354550
  • ENSP00000346557
  • ENST00000380572
  • ENSP00000369946
  • ENST00000380573
  • ENSP00000369947
  • ENST00000380582
  • ENSP00000369956
  • ENST00000380586
  • ENSP00000369960
  • ENST00000519096
  • ENSP00000431073
  • ENST00000521711
  • ENSP00000430414

Symbol
  • ADRA1C
  • ADRA1C
  • ADRA1L1
  • ALPHA1AAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.99
biological process
0.97
chemical
0.85
disease
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.29   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.29   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 971
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 41
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
43.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
43.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor alpha 1A
VGNC:923
472723
Macaque
adrenoceptor alpha 1A
712509
Mouse
MGI:104773
11549
Rat
RGD:2055
29412
Dog
adrenoceptor alpha 1A
VGNC:37672
403866
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adrenoceptor alpha 1A
Macaque
adrenoceptor alpha 1A
Mouse
Rat
Dog
adrenoceptor alpha 1A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35348-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Adrenoceptors (R-HSA-390696)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (12/13) signalling events
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Adrenoceptors
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (12/13) signalling events
G alpha (q) signalling events
Protein-Protein Interactions (238)
1 – 10 of 238
GNA13
Tbio
Novelty: 0.04149138
Score: 0.965
Data Source: Reactome,STRINGDB
TAC1
Tbio
Novelty: 0.00006575
Score: 0.963
Data Source: STRINGDB
EDN1
Tbio
Novelty: 0.00007453
Score: 0.958
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.958
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.955
Data Source: STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.954
Data Source: STRINGDB
OXT
Tbio
Novelty: 0.00005116
Score: 0.953
Data Source: STRINGDB
ARHGEF12
Tbio
Novelty: 0.01365866
Score: 0.953
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.951
Data Source: STRINGDB
GNA15
Tbio
Novelty: 0.00159196
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  272.29

PubMed score by year
PubTator Score  204.72

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer