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Tbio
SPRR2A
Small proline-rich protein 2A

Protein Summary
Description
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392653
  • ENSP00000376423
  • ENSG00000241794
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.47
disease
0.43
interacting protein
0.41
tissue
0.39
biological term
0.37


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.61   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.61   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at onset
1
1
1
32.8
2
1
2
32.8
vitamin D measurement
1
1
1
21.1
monocyte count
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at onset
1
32.8
2
32.8
vitamin D measurement
1
21.1
monocyte count
1
10.3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P35326-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (66)
1 – 10 of 66
SPRR2E
Tdark
Novelty:  0.78347788
Score:  0.983
Data Source:  STRINGDB
SPRR1A
Tbio
Novelty:  0.04328986
Score:  0.982
Data Source:  STRINGDB
SPRR2D
Tdark
Novelty:  0.28543054
Score:  0.982
Data Source:  STRINGDB
SPRR1B
Tbio
Novelty:  0.0320028
Score:  0.978
Data Source:  STRINGDB
SPRR3
Tbio
Novelty:  0.0241484
Score:  0.969
Data Source:  STRINGDB
LCE3E
Tdark
Novelty:  0.72118892
Score:  0.967
Data Source:  STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.965
Data Source:  STRINGDB
LCE3D
Tbio
Novelty:  0.20614547
Score:  0.962
Data Source:  STRINGDB
SPRR2F
Tdark
Novelty:  0.35614731
Score:  0.959
Data Source:  STRINGDB
LOR
Tbio
Novelty:  0.0033781
Score:  0.954
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.61

PubMed score by year
PubTator Score  14.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer