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Tbio
SPRR1A
Cornifin-A

Protein Summary
Description
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368762
  • ENSP00000357751
  • ENSG00000169474

Symbol
  • SPRK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
PubMedID
0.71
small molecule perturbation
0.68
cell type or tissue
0.58
disease perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.86   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.86   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (93)
1 – 10 of 93
SPRR1B
Tbio
Novelty:  0.0320028
Score:  0.986
Data Source:  STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.985
Data Source:  STRINGDB
SPRR2A
Tbio
Novelty:  0.07065019
Score:  0.982
Data Source:  STRINGDB
SPRR2E
Tdark
Novelty:  0.78347788
Score:  0.973
Data Source:  STRINGDB
LOR
Tbio
Novelty:  0.0033781
Score:  0.971
Data Source:  STRINGDB
SPRR2D
Tdark
Novelty:  0.28543054
Score:  0.97
Data Source:  STRINGDB
SPRR2B
Tdark
Novelty:  0.36342019
Score:  0.969
Data Source:  STRINGDB
SPRR3
Tbio
Novelty:  0.0241484
Score:  0.968
Data Source:  STRINGDB
TCHH
Tbio
Novelty:  0.00303837
Score:  0.966
Data Source:  STRINGDB
LELP1
Tbio
Novelty:  0.70511274
Score:  0.963
Data Source:  STRINGDB
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1.1
79.6
2
2
0
1.2
60.4
age at onset
1
1
1
32.8
granulocyte count
1
1
1
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
79.6
0
1.2
60.4
age at onset
1
32.8
granulocyte count
1
3.5
Publication Statistics
PubMed Score 23.86
PubMed score by year
PubTator Score 17.23
PubTator score by year